Animal experimentation is necessary to characterize human diseases and design adequate
therapeutic interventions. In renal transplantation research, the limited number of in vitro …

Optimizing kidney preservation is a primary issue in transplantation, particularly in relation to
new donor sources, such as expanded criteria donors (ECDs) and donation after cardiac …

Background Deceased donor kidneys are preserved in cold hypoxic conditions. Providing
oxygen during preservation might improve post-transplant outcomes, particularly for kidneys …

The increased demand for organs has led to the increased usage of “higher risk” kidney and
liver grafts. These grafts from donation after circulatory death or expanded criteria donors …

The final decision to accept an organ for transplantation remains a subjective one. With
“poor organ quality” commonly cited as a major reason for kidney discard, accurate …

Background: The two main options for renal allograft preservation are static cold storage
(CS) and machine perfusion (MP). There has been considerably increased interest in MP …

Acceptance criteria of deceased donor organs have gradually been extended toward
suboptimal quality, posing an urgent need for more objective pre‐transplant organ …

Hypothermic machine preservation (HMP) has been used in renal transplantation since the
late 1960s with recent robust prospective, multicenter data showing lower rates of delayed …

Improving preservation techniques to minimize injury is of particular importance in organs
from marginal donors. Since the introduction of transplantation and routine use of …

Kidney transplantation is the treatment of choice for end-stage renal disease. Despite its
superiority over dialysis, the persisting organ shortage remains a major drawback …