The utility of immunohistochemical detection of DNA mismatch repair (MMR) protein in
screening colorectal tumors for hereditary nonpolyposis colorectal cancer (HNPCC) …

Mutations in the DNA mismatch repair (MMR) genes are associated with the inheritance of
hereditary non‐polyposis colorectal cancer, also known as Lynch syndrome, a cancer …

Intensive research efforts during the last several decades have increased our understanding
of carcinogenesis, and have identified a genetic basis for the multi-step process of cancer …

The stem-loop in the 5′ untranslated region (UTR) of collagen α1 (I) and α2 (I) mRNAs (5′
SL) is the key element regulating their stability and translation. Stabilization of collagen …

We investigated a family with an autosomal recessive syndrome of café-au-lait patches and
childhood malignancy, notably supratentorial primitive neuroectodermal tumor. There was …

Purpose Patients with Lynch syndrome are at risk for upper tract urothelial carcinoma. We
sought to identify the incidence and most reliable means of point of care screening for Lynch …

Type I collagen is the most abundant protein in the human body, produced by folding of two
α1 (I) polypeptides and one α2 (I) polypeptide into the triple helix. A conserved stem–loop …

There are two commonly accepted methods for detecting microsatellite status. One is to
detect amplified microsatellite loci by polymerase chain reaction (PCR) and the other is to …

Type I collagen is composed of 2 polypeptides, α1 (I) and α2 (I), which fold into triple helix.
Collagen α1 (I) and α2 (I) mRNAs have a conserved stem-loop structure in their 5'UTRs, the …

Type I collagen is the most abundant protein in the human body. Its excessive synthesis
results in fibrosis of various organs. Fibrosis is a major medical problem without an existing …