How low-level psychological stress and overnutrition interact in influencing cardiometabolic
disease is unclear. Mechanistic overlaps suggest potential synergies; however, findings are …

Obesity is generally associated with low-grade chronic inflammation that involves the
recruitment of macrophages and other inflammation factors to the adipocytes of obese …

We recently reported that non-preconditioned hearts from diet-induced obese rats showed,
compared to controls, a significant reduction in infarct size after ischaemia/reperfusion …

Purpose By increasing circulating free fatty acids and the rate of fatty acid oxidation, obesity
decreases glucose oxidation and myocardial tolerance to ischemia. Partial inhibition of fatty …

Several studies have shown the role of microRNAs (miRNAs) in myocardial dysfunction in
response to ischemia/reperfusion (I/R). In this study, we investigated the impact of high fat …

The metabolic syndrome is recognized as a cluster of disturbances associated with obesity,
type 2 diabetes and hypertension. Over the past two decades, the number of people with the …

An ischemic insult is accompanied by an acute increase in circulating fatty acid (FA) levels,
which can induce adverse changes related to cardiac metabolism/energetics. Although …

We explored whether dietary-induced obesity hastens the transition from concentric left
ventricular (LV) hypertrophy to pump dysfunction in spontaneously hypertensive rats (SHRs) …

Obesity increases the incidence of cardiac arrhythmias and impairs wound healing.
However, it is presently unknown whether a high-fat diet affects arrhythmic risk or wound …

Normal insulin sensitivity is essential for the maintenance of normal circulating carbohydrate
and lipid levels and their metabolism. In healthy individuals elevated blood glucose levels …