The cellular and physiological basis for lung repair and regeneration: past, present, and future

MC Basil, J Katzen, AE Engler, M Guo, MJ Herriges… - Cell stem cell, 2020 - cell.com
The respiratory system, which includes the trachea, airways, and distal alveoli, is a complex
multi-cellular organ that intimately links with the cardiovascular system to accomplish gas …

The comparable efficacy of lung donation after circulatory death and brain death: a systematic review and meta-analysis

J Zhou, B Chen, H Liao, Z Wang, M Lyu, S Man… - …, 2019 - journals.lww.com
Background. Lung transplantations (LTx) have become an effective lifesaving treatment for
patients with end-stage lung diseases. While the shortage of lung donor pool and severe …

[HTML][HTML] Physiologic changes in the heart following cessation of mechanical ventilation in a porcine model of donation after circulatory death: implications for cardiac …

CW White, R Lillico, J Sandha, D Hasanally… - American Journal of …, 2016 - Elsevier
Hearts donated following circulatory death (DCD) may represent an additional source of
organs for transplantation; however, the impact of donor extubation on the DCD heart has …

Acellular hypothermic extracorporeal perfusion extends allowable ischemia time in a porcine whole limb replantation model

M Kueckelhaus, A Dermietzel, M Alhefzi… - Plastic and …, 2017 - journals.lww.com
Background: One of the major challenges in traumatic amputation is the need to keep
ischemia time brief (4 to 6 hours) to avoid ischemic damage and enable successful …

Cross-circulation for extracorporeal support and recovery of the lung

JD O'Neill, BA Guenthart, J Kim, S Chicotka… - Nature Biomedical …, 2017 - nature.com
The shortage of transplantable donor organs has profound consequences, especially for
patients with end-stage lung disease, for which transplantation remains the only definitive …

Cell replacement in human lung bioengineering

BA Guenthart, JD O'Neill, J Kim, K Fung… - The Journal of Heart and …, 2019 - Elsevier
BACKGROUND As the number of patients with end-stage lung disease continues to rise,
there is a growing need to increase the limited number of lungs available for transplantation …

The neurology of death and the dying brain: a pictorial essay

D Kondziella - Frontiers in Neurology, 2020 - frontiersin.org
As neurologists earn their living with the preservation and restoration of brain function, they
are also well-positioned to address the science behind the transition from life to death. This …

Lung injury repair by transplantation of adult lung cells following preconditioning of recipient mice

I Milman Krentsis, C Rosen, E Shezen… - Stem cells …, 2018 - academic.oup.com
Repair of injured lungs represents a longstanding therapeutic challenge. We recently
demonstrated that human and mouse embryonic lung tissue from the canalicular stage of …

Public opinion and legislations related to brain death, circulatory death and organ donation

MH Othman, A Dutta, D Kondziella - Journal of the Neurological Sciences, 2020 - Elsevier
Background It is poorly understood how public perception of the difference between brain
death and circulatory death may influence attitudes towards organ donation. We …

Expression analysis of long non-coding RNAs in a renal ischemia-reperfusion injury model

Q Tao, W Tianyu, Z Jiangqiao, C Zhongbao… - Acta Cirurgica …, 2019 - SciELO Brasil
Purpose: To investigate the long non-coding RNAs (lncRNAs) profile on renal ischemia
reperfusion in a mouse model. Methods: Microarray analysis was used to study the …