Emerging natural-product-based treatments for the management of osteoarthritis
ML Pérez-Lozano, A Cesaro, M Mazor, E Esteve… - Antioxidants, 2021 - mdpi.com
Osteoarthritis (OA) is a complex degenerative disease in which joint homeostasis is
disrupted, leading to synovial inflammation, cartilage degradation, subchondral bone …
disrupted, leading to synovial inflammation, cartilage degradation, subchondral bone …
Restoration of autophagic flux rescues oxidative damage and mitochondrial dysfunction to protect against intervertebral disc degeneration
L Kang, Q Xiang, S Zhan, Y Song… - Oxidative medicine …, 2019 - Wiley Online Library
Oxidative stress‐induced mitochondrial dysfunction and nucleus pulposus (NP) cell
apoptosis play crucial roles in the development of intervertebral disc degeneration (IDD) …
apoptosis play crucial roles in the development of intervertebral disc degeneration (IDD) …
Phytochemicals against osteoarthritis by inhibiting apoptosis
H Kong, JJ Han, G Dmitrii, X Zhang - Molecules, 2024 - mdpi.com
Osteoarthritis (OA) is a chronic joint disease that causes pathological changes in articular
cartilage, synovial membrane, or subchondral bone. Conventional treatments for OA include …
cartilage, synovial membrane, or subchondral bone. Conventional treatments for OA include …
Evaluation of the articular cartilage in the knees of rats with induced arthritis treated with curcumin
This study was designed to evaluate the anti-inflammatory effects of a curcumin treatment on
the knee of rats with induced osteoarthritis. Fifteen adult rats were used and divided in three …
the knee of rats with induced osteoarthritis. Fifteen adult rats were used and divided in three …
Chemically modified curcumin (CMC2. 24) alleviates osteoarthritis progression by restoring cartilage homeostasis and inhibiting chondrocyte apoptosis via the NF-κB …
Y Zhou, J Ming, M Deng, Y Li, B Li, J Li, Y Ma… - Journal of Molecular …, 2020 - Springer
The disorders of cartilage homeostasis and chondrocyte apoptosis are major events in the
pathogenesis of osteoarthritis (OA). Herein, we aim to assess the chondroprotective effect …
pathogenesis of osteoarthritis (OA). Herein, we aim to assess the chondroprotective effect …
[HTML][HTML] Curcumin exerts a protective effect on murine knee chondrocytes treated with IL-1β through blocking the NF-κB/HIF-2α signaling pathway
P Wang, Y Ye, W Yuan, Y Tan, S Zhang… - Annals of Translational …, 2021 - ncbi.nlm.nih.gov
Background Osteoarthritis (OA) is characterized by erosion and degradation of articular
cartilage. This study assessed the effects of curcumin on mouse knee cartilage …
cartilage. This study assessed the effects of curcumin on mouse knee cartilage …
[HTML][HTML] Involvement of TLR4 in the protective effect of intra-articular administration of curcumin on rat experimental osteoarthritis
D Yan, B He, J Guo, S Li, J Wang - Acta Cirurgica Brasileira, 2019 - SciELO Brasil
Purpose In view of the principal role of Toll-like receptor 4 (TLR4) in mediating sterile
inflammatory response contributing to osteoarthritis (OA) pathogenesis, we used …
inflammatory response contributing to osteoarthritis (OA) pathogenesis, we used …
Protective effects of Platycodon grandiflorus polysaccharides against apoptosis induced by carbonyl cyanide 3-chlorophenylhydrazone in 3D4/21 cells
C Wang, G Cheng, S Yang, L Li, Y Zhang… - International journal of …, 2019 - Elsevier
This study aimed to investigate the potential protective effects of Platycodon grandiflorus
polysaccharide (PGPS) on carbonyl cyanide 3-chlorophenylhydrazone (CCCP)-induced …
polysaccharide (PGPS) on carbonyl cyanide 3-chlorophenylhydrazone (CCCP)-induced …
Exploiting Curcumin Synergy With Natural Products Using Quantitative Analysis of Dose–Effect Relationships in an Experimental In Vitro Model of Osteoarthritis
Introduction: Drug combination is widely used to treat chronic inflammatory diseases. A
similar strategy might be worth of interest to design plant-derived natural products to treat …
similar strategy might be worth of interest to design plant-derived natural products to treat …
Inflammatory phenotype of osteoarthritis and its potential therapies
Y Cao, S Tang, C Ding - Rheumatology & Autoimmunity, 2021 - mednexus.org
Introduction: Osteoarthritis (OA) is the most common joint disorder in the world but there are
no approved therapies to slow disease progression. Historically, OA has been considered a …
no approved therapies to slow disease progression. Historically, OA has been considered a …