Prostate cancer (PCa) affects millions of men globally. Due to advances in understanding
genomic landscapes and biological functions, the treatment of PCa continues to improve …

Immune checkpoint inhibitor (ICI) activates host's anti-tumor immune response by blocking
negative regulatory immune signals. A series of clinical trials showed that ICI could …

Combination therapy, a treatment modality that combines two or more therapeutic agents, is
a cornerstone of cancer therapy. The amalgamation of anti-cancer drugs enhances efficacy …

Tumor growth and metastasis rely on tumor vascular network for the adequate supply of
oxygen and nutrients. Tumor angiogenesis relies on a highly complex program of growth …

Tumors are influenced by the mechanical properties of their microenvironment. Using
patient samples and atomic force microscopy, we found that tissue stiffness is higher in liver …

Angiogenesis is defined as the formation of new blood vessels from preexisting vessels and
has been characterized as an essential process for tumor cell proliferation and viability. This …

Circular RNAs (circRNAs), which are single-stranded closed-loop RNA molecules lacking
terminal 5′ caps and 3′ poly (A) tails, are attracting increasing scientific attention for their …

Ten antiangiogenic drugs targeting VEGF or its receptors are approved for cancer treatment.
However, these agents, intended to block tumors' blood supply, may cause hypoxia, which …

Abstract Aberrant N 6-methyladenosine (m6A) modification has emerged as a driver of
tumor initiation and progression, yet how long noncoding RNAs (lncRNA) are involved in the …

Angiogenesis, or the formation of new capillary blood vessels, occurs primarily during
human development and reproduction; however, aberrant regulation of angiogenesis is also …