Cryo-electron microscopy-based drug design

E Cebi, J Lee, VK Subramani, N Bak, C Oh… - Frontiers in Molecular …, 2024 - frontiersin.org
Structure-based drug design (SBDD) has gained popularity owing to its ability to develop
more potent drugs compared to conventional drug-discovery methods. The success of …

Changes in chronic myeloid leukemia treatment modalities and outcomes after introduction of second-generation tyrosine kinase inhibitors as first-line therapy: a multi …

N Iriyama, E Iwanaga, Y Kimura, N Watanabe… - International Journal of …, 2024 - Springer
This study investigated changes in treatment modalities and outcomes of chronic myeloid
leukemia in the chronic phase (CP-CML) after the approval of second-generation tyrosine …

[PDF][PDF] Endothelial function in patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors is not related to cardiovascular risk assessed by SCORE2 …

E Szczepanek, B Marczyk, O Chukwu, S Chłopicki… - 2024 - ruj.uj.edu.pl
Abstract Introduction Tyrosine kinase inhibitors (TKIs) revolutionized the treatment of chronic
myeloid leukemia (CML) but are endowed with negative effects on endothelial function …