Drug targeting Nsp1-ribosomal complex shows antiviral activity against SARS-CoV-2

M Afsar, R Narayan, MN Akhtar, D Das, H Rahil… - Elife, 2022 - elifesciences.org
Abstract The SARS-CoV-2 non-structural protein 1 (Nsp1) contains an N-terminal domain
and C-terminal helices connected by a short linker region. The C-terminal helices of Nsp1 …

SCovid: single-cell atlases for exposing molecular characteristics of COVID-19 across 10 human tissues

C Qi, C Wang, L Zhao, Z Zhu, P Wang… - Nucleic Acids …, 2022 - academic.oup.com
Abstract SCovid (http://bio-annotation. cn/scovid) aims at providing a comprehensive
resource of single-cell data for exposing molecular characteristics of coronavirus disease …

Long-term memory CD8+ T cells specific for SARS-CoV-2 in individuals who received the BNT162b2 mRNA vaccine

N Kuse, Y Zhang, T Chikata, HT Nguyen, S Oka… - Nature …, 2022 - nature.com
Long-term memory T cells have not been well analyzed in individuals vaccinated with a
COVID-19 vaccine although analysis of these T cells is necessary to evaluate vaccine …

SARS-CoV-2 genomic analyses in cancer patients reveal elevated intrahost genetic diversity

JD Siqueira, LR Goes, BM Alves, PS Carvalho… - Virus …, 2021 - academic.oup.com
Numerous factors have been identified to influence susceptibility to Severe Acute
Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection and disease severity. Cancer …

Amilorides inhibit SARS-CoV-2 replication in vitro by targeting RNA structures

M Zafferani, C Haddad, L Luo, J Davila-Calderon… - Science …, 2021 - science.org
The SARS-CoV-2 pandemic, and the likelihood of future coronavirus pandemics,
emphasized the urgent need for development of novel antivirals. Small-molecule chemical …

A conceptual model for geo-online exploratory data visualization: The case of the covid-19 pandemic

A Bernasconi, S Grandi - Information, 2021 - mdpi.com
Responding to the recent COVID-19 outbreak, several organizations and private citizens
considered the opportunity to design and publish online explanatory data visualization tools …

Mutagenesis and structural studies reveal the basis for the specific binding of SARS-CoV-2 SL3 RNA element with human TIA1 protein

D Zhang, L Qiao, X Lei, X Dong, Y Tong… - Nature …, 2023 - nature.com
Viral RNA-host protein interactions are indispensable during RNA virus transcription and
replication, but their detailed structural and dynamical features remain largely elusive. Here …

A comprehensive review of the analysis and integration of omics data for SARS-CoV-2 and COVID-19

Z Zhu, S Zhang, P Wang, X Chen, J Bi… - Briefings in …, 2022 - academic.oup.com
Since the first report of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in
December 2019, over 100 million people have been infected by COVID-19, millions of …

VirusViz: comparative analysis and effective visualization of viral nucleotide and amino acid variants

A Bernasconi, A Gulino, T Alfonsi… - Nucleic Acids …, 2021 - academic.oup.com
Variant visualization plays an important role in supporting the viral evolution analysis,
extremely valuable during the COVID-19 pandemic. VirusViz is a web-based application for …

Structure-based drug repurposing against COVID-19 and emerging infectious diseases: methods, resources and discoveries

Y Masoudi-Sobhanzadeh, A Salemi… - Briefings in …, 2021 - academic.oup.com
To attain promising pharmacotherapies, researchers have applied drug repurposing (DR)
techniques to discover the candidate medicines to combat the coronavirus disease 2019 …