Tumor cells and neovasculature dual targeting delivery for glioblastoma treatment
Glioblastoma multiforme (GBM), one of the most common primary malignant brain tumors,
was characterized by angiogenesis and tumor cells proliferation. Antiangiogenesis and …
was characterized by angiogenesis and tumor cells proliferation. Antiangiogenesis and …
Immunotherapeutic vitamin E nanoemulsion synergies the antiproliferative activity of paclitaxel in breast cancer cells via modulating Th1 and Th2 immune response
Paclitaxel (PTX) is used as first line treatment for metastatic breast cancer but the relief
comes at a heavy cost in terms of accompanying adverse effects. The pharmaceutical …
comes at a heavy cost in terms of accompanying adverse effects. The pharmaceutical …
Neuropharmacokinetic evaluation of lactoferrin-treated indinavir-loaded nanoemulsions: remarkable brain delivery enhancement
Z Karami, MR Saghatchi Zanjani… - Drug Development …, 2019 - Taylor & Francis
Abstract Objective: Indinavir (IDV), an antiretroviral protease inhibitor used in treatment of
HIV infection, has limited entry into brain due to efflux by the P-glycoprotein presented in …
HIV infection, has limited entry into brain due to efflux by the P-glycoprotein presented in …
Study and evaluation of mechanisms of dual targeting drug delivery system with tumor microenvironment assays compared with normal assays
A dual targeting delivery system was developed to completely conquer the two barriers that
glioma treatment faces: the blood–brain barrier (BBB) and the brain–glioma barrier …
glioma treatment faces: the blood–brain barrier (BBB) and the brain–glioma barrier …
Tumor homing cell penetrating peptide decorated nanoparticles used for enhancing tumor targeting delivery and therapy
Specific targeting ability and good tissue penetration are two critical requirements for tumor
targeted delivery systems. Systematical selected peptides from a library may meet these two …
targeted delivery systems. Systematical selected peptides from a library may meet these two …
Fluorescent carbonaceous nanodots for noninvasive glioma imaging after angiopep-2 decoration
S Ruan, J Qian, S Shen, J Chen, J Zhu… - Bioconjugate …, 2014 - ACS Publications
Fluorescent carbonaceous nanodots (CDs) have attracted much attention due to their
unique properties. However, their application in noninvasive imaging of diseased tissues …
unique properties. However, their application in noninvasive imaging of diseased tissues …
In vitro and in vivo intracellular distribution and anti-glioblastoma effects of docetaxel-loaded nanoparticles functioned with IL-13 peptide
An active targeting delivery system helps increase intracellular drug delivery, which is
promising for the treatment of glioblastoma. Interleukin 13 (IL-13) peptide which was derived …
promising for the treatment of glioblastoma. Interleukin 13 (IL-13) peptide which was derived …
Incorporation of lapatinib into core–shell nanoparticles improves both the solubility and anti-glioma effects of the drug
Purpose Lapatinib is a dual EGFR and HER2 inhibitor that is used to treat HER2-
overexpressing cancers. However, its poor water solubility hinders its clinical use …
overexpressing cancers. However, its poor water solubility hinders its clinical use …
An injectable acellular matrix scaffold with absorbable permeable nanoparticles improves the therapeutic effects of docetaxel on glioblastoma
HL Xu, KL Mao, CT Lu, ZL Fan, JJ Yang, J Xu, PP Chen… - Biomaterials, 2016 - Elsevier
Intratumoral drug delivery (IT) is an inherently appealing approach for concentrating toxic
chemotherapies at the site of action. However, for most chemotherapies, poor tumor …
chemotherapies at the site of action. However, for most chemotherapies, poor tumor …
Delivering siRNA and chemotherapeutic molecules across BBB and BTB for intracranial glioblastoma therapy
For aggressive brain glioblastoma, the therapy is significantly impaired by blood–brain
barrier (BBB) and blood–tumor barrier (BTB). Choosing more than one target from the pool …
barrier (BBB) and blood–tumor barrier (BTB). Choosing more than one target from the pool …