This review summarizes current knowledge about the mechanisms of timely binding and
dissociation of two nucleoid proteins, IHF and Fis, which play fundamental roles in the …

The DnaA protein has long been considered to play the key role in the initiation of
chromosome replication in modern bacteria. Many questions about this role, however …

For DNA replication initiation in Bacteria, replication initiation proteins bind to double-
stranded DNA (dsDNA) and interact with single-stranded DNA (ssDNA) at the replication …

Timely initiation of chromosomal DNA replication in Escherichia coli is achieved by cell cycle-
coordinated regulation of the replication origin, oriC, and the replication initiator, ATP-DnaA …

Although the mechanism of DNA replication initiation has been investigated for over 50
years, many important discoveries have been made related to this process in recent years …

Computational models of cells cannot be considered complete unless they include the most
fundamental process of life, the replication of genetic material. In a recent study, we …

The DnaA protein has long been considered to play the key role in the initiation of
chromosome replication in modern bacteria. Many questions about this role, however …

Initiation of chromosomal replication requires dynamic nucleoprotein complexes. In most
eubacteria, the origin oriC contains multiple DnaA box sequences to which the ubiquitous …

A fundamental problem in biology is how cells obtain the reproducible, coherent phenotypes
needed for natural selection to act or, put differently, how cells manage to limit their …

Computational models of cells cannot be considered complete unless they include the most
fundamental process of life, the replication and inheritance of genetic material. By creating a …