It has been more than 10 years since the hopes for disease modeling and drug discovery
using induced pluripotent stem cell (iPSC) technology boomed. Recently, clinical trials have …

In the last few years, our understanding of disease molecular mechanisms underpinning
ALS has advanced greatly, allowing the first steps in translating into clinical practice novel …

Background The key pathological signature of ALS/FTLD is the mis-localization of
endogenous TDP-43 from the nucleus to the cytoplasm. However, TDP-43 gain of function in …

Background and Objectives Altered metabolism is observed in amyotrophic lateral sclerosis
(ALS). However, without a standardized methodology to define metabolic changes, our …

The integrity of the blood-CSF barrier plays a major role in inflammation, but also in
shielding the central nervous system from external and systemic–potentially toxic–factors …

Amyotrophic Lateral Sclerosis (ALS) is considered the prototype of motor neuron disease,
characterized by motor neuron loss and muscle waste. A well-established pathogenic …

Background Epigenetics contributes to the pathogenesis of amyotrophic lateral sclerosis
(ALS). We aimed to characterize the DNA methylation profiles associated with clinical …

Abstract Background and Objective Amyotrophic lateral sclerosis (ALS) causes motor
neuron loss and progressive paralysis. While traditionally viewed as motor neuron disease …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by
the progressive degeneration of both upper and lower motor neurons. A defining …

Introduction This study sought to identify the optimal caloric intake to improve function and
survival in ALS patients by comparing oral intake per ideal body weight (IBW) and its …