The CXCL12-CXCR4/CXCR7 axis as a mechanism of immune resistance in gastrointestinal malignancies
SK Daniel, YD Seo, VG Pillarisetty - Seminars in cancer biology, 2020 - Elsevier
Single agent checkpoint inhibitor therapy has not been effective for most gastrointestinal
solid tumors, but combination therapy with drugs targeting additional immunosuppressive …
solid tumors, but combination therapy with drugs targeting additional immunosuppressive …
[HTML][HTML] The role of the CXCL12/CXCR4/ACKR3 axis in autoimmune diseases
EM García-Cuesta, CA Santiago… - Frontiers in …, 2019 - frontiersin.org
Chemokine receptors are members of the G protein-coupled receptor superfamily. These
receptors are intimately involved in cell movement, and thus play a critical role in several …
receptors are intimately involved in cell movement, and thus play a critical role in several …
Pathological roles of the homeostatic chemokine CXCL12
R Janssens, S Struyf, P Proost - Cytokine & growth factor reviews, 2018 - Elsevier
CXCL12 is a CXC chemokine that traditionally has been classified as a homeostatic
chemokine. It contributes to physiological processes such as embryogenesis, hematopoiesis …
chemokine. It contributes to physiological processes such as embryogenesis, hematopoiesis …
Lactobacillus rhamnosus GG protects the intestinal epithelium from radiation injury through release of lipoteichoic acid, macrophage activation and the migration of …
TE Riehl, D Alvarado, X Ee, A Zuckerman, L Foster… - Gut, 2019 - gut.bmj.com
Objective Lactobacillus rhamnosus GG (LGG), a probiotic, given by gavage is
radioprotective of the mouse intestine. LGG-induced radioprotection is toll-like receptor 2 …
radioprotective of the mouse intestine. LGG-induced radioprotection is toll-like receptor 2 …
Emerging roles for noncanonical NF-κB signaling in the modulation of inflammatory bowel disease pathobiology
DK McDaniel, K Eden, VM Ringel… - Inflammatory bowel …, 2016 - academic.oup.com
Crohn's disease and ulcerative colitis are common and debilitating manifestations of
inflammatory bowel disease (IBD). IBD is characterized by a radical imbalance in the …
inflammatory bowel disease (IBD). IBD is characterized by a radical imbalance in the …
CXCR4 antagonist AMD3100 (plerixafor): From an impurity to a therapeutic agent
J Wang, BA Tannous, MC Poznansky, H Chen - Pharmacological research, 2020 - Elsevier
Abstract AMD3100 (plerixafor), a CXCR4 antagonist, has opened a variety of avenues for
potential therapeutic approaches in different refractory diseases. The CXCL12/CXCR4 axis …
potential therapeutic approaches in different refractory diseases. The CXCL12/CXCR4 axis …
Targeting chemokine receptors in chronic inflammatory diseases: an extensive review
PJ Koelink, SA Overbeek, S Braber, P de Kruijf… - Pharmacology & …, 2012 - Elsevier
The traffic of the different types of immune cells is an important aspect in the immune
response. Chemokines are soluble peptides that are able to attract cells by interaction with …
response. Chemokines are soluble peptides that are able to attract cells by interaction with …
[HTML][HTML] Development of a unique small molecule modulator of CXCR4
Z Liang, W Zhan, A Zhu, Y Yoon, S Lin, M Sasaki… - PloS one, 2012 - journals.plos.org
Background Metastasis, the spread and growth of tumor cells to distant organ sites,
represents the most devastating attribute and plays a major role in the morbidity and …
represents the most devastating attribute and plays a major role in the morbidity and …
Functional diversity of SDF-1 splicing variants
M Janowski - Cell adhesion & migration, 2009 - Taylor & Francis
SDF-1 is ubiquitously expressed in vertebrate tissues in a constitutive manner. It performs an
essential role in cell migration and proliferation as well as participates in tissue-specific …
essential role in cell migration and proliferation as well as participates in tissue-specific …
miR-141 Regulates colonic leukocytic trafficking by targeting CXCL12β during murine colitis and human Crohn's disease
Z Huang, T Shi, Q Zhou, S Shi, R Zhao, H Shi, L Dong… - Gut, 2014 - gut.bmj.com
Objective Emerging evidence suggests that microRNA (miRNA)-mediated gene regulation
influences a variety of autoimmune disease processes, including Crohn's disease (CD), but …
influences a variety of autoimmune disease processes, including Crohn's disease (CD), but …