Methods: We evaluated the expression patterns of 11 candidate miRNAs using quantitative
real-time PCR in whole blood (n= 10) and muscle biopsy samples (n= 9) of DM1 patients …

Background Myotonic dystrophy type 1 (DM1) is a multisystemic disorder characterized by
progressive cardiac conduction impairment, arrhythmias, and sudden death. Mexiletine is a …

Die autosomal dominanten dystrophischen Myotonien dystrophia myotonica Typ-1 (DM1,
Curschmann-Steinert-Erkrankung) und dystrophia myotonica Typ-2 (DM2, proximale …

Muscular dystrophies (MD) represent a heterogeneous group of rare genetic diseases that
often lead to significant weakness due to progressive muscle degeneration. In many forms of …

Introduction: To evaluate myocardial strain and extracellular volume in myotonic dystrophy
type 1 (DM1) patients as potential imaging biomarkers of subclinical cardiac pathology …

1.6±2.6; P= 0.582). Native T1 relaxation times were prolonged in DM patients compared with
control subjects (1018.8±37.9 versus 970.3±29.9 ms; P< 0.0001). ECV measures were also …

Background Myotonic dystrophy type 1 (DM1), a muscular dystrophy due to CTG expansion
in the DMPK gene, can cause cardiac conduction disorders and sudden death. These …

Objective High sensitivity plasma cardiac troponin-I (cTnI) is emerging as a strong predictor
of cardiac events in a variety of settings. We have explored its utility in patients with myotonic …

Measurement of muscle strength is fundamental for the management of patients with
myotonic dystrophy type 1 (DM1). Nevertheless, guidance on this topic is somewhat limited …

Neuromuscular diseases (NMDs) include a broad spectrum of disorders that affect motor
unit in every possible site, extending from the cell body of peripheral nerves to the muscle …