Mendelian randomization as a tool to gain insights into the mosaic causes of autoimmune diseases

C Chen, P Wang, RD Zhang, Y Fang, LQ Jiang… - Autoimmunity …, 2022 - Elsevier
Autoimmune diseases (ADs) are a broad range of disorders which are characterized by long-
term inflammation and tissue damage arising from an immune response against one's own …

Marginal effects—quantifying the effect of changes in risk factors in logistic regression models

EC Norton, BE Dowd, ML Maciejewski - Jama, 2019 - jamanetwork.com
Marginal effects can be used to express how the predicted probability of a binary outcome
changes with a change in a risk factor. For example, how does 1-year mortality risk change …

Acidification of the lysosome-like vacuole and the vacuolar H+-ATPase are deficient in two yeast mutants that fail to sort vacuolar proteins.

JH Rothman, CT Yamashiro, CK Raymond… - The Journal of cell …, 1989 - rupress.org
Organelle acidification plays a demonstrable role in intracellular protein processing,
transport, and sorting in animal cells. We investigated the relationship between acidification …

[HTML][HTML] Real-world evidence of the herb-drug interactions

HY Pan, LW Wu, PC Wang, PH Chiu… - Journal of Food and …, 2022 - ncbi.nlm.nih.gov
Herbal medicine (HM) is a type of medicine that uses active ingredients made from plants to
treat diseases and maintain health and wellbeing. Due to its increasing worldwide usage …

The new FDA real-world evidence program to support development of drugs and biologics

DC Klonoff - Journal of diabetes science and technology, 2020 - journals.sagepub.com
FDA has launched a Real World Evidence (RWE) Program for using real-world evidence
(RWE) to help support new indications for already approved drugs or biologics and …

Estimating risk ratio from any standard epidemiological design by doubling the cases

Y Ning, A Lam, M Reilly - BMC Medical Research Methodology, 2022 - Springer
Background Despite the ease of interpretation and communication of a risk ratio (RR), and
several other advantages in specific settings, the odds ratio (OR) is more commonly reported …

Colchicine and risk of hospitalization due to COVID‐19: A population‐based study

M Sáenz‐Aldea, Á Salgado‐Barreira… - Journal of Medical …, 2023 - Wiley Online Library
Colchicine is one of the most widely studied and best‐known anti‐inflammatory treatments.
This study aimed to assess the effect of colchicine on risk of hospitalization due to COVID …

How to choose your study design

CM Mellis - Journal of paediatrics and child health, 2020 - Wiley Online Library
Research designs are broadly divided into observational studies (ie cross‐sectional; case–
control and cohort studies) and experimental studies (randomised control trials, RCTs). Each …

Permanent childhood hearing impairment in infants admitted to the neonatal intensive care unit: nested case–control study

V Nair, S Janakiraman, S Whittaker, J Quail… - European Journal of …, 2021 - Springer
The prevalence of permanent childhood hearing impairment (PCHI) in infants admitted to a
neonatal intensive care unit (NICU) is higher than that in the general population. Our study …

What are risk factors for an ileus after posterior spine surgery?—a case control study

E Yilmaz, E Benca, AP Patel, S Hopkins… - Global Spine …, 2022 - journals.sagepub.com
Study design: Case-Control Study. Objective: The purpose of this retrospective study is to
evaluate risk factors for developing a postoperative ileus after posterior spine surgery …