Alzheimer's disease (AD) 1− 3 is the most common form of dementia (estimated∼ 50− 60%
of all cases), associated with loss of memory (in particular episodic memory), cognitive …

The demographics of aging suggest a great need for the early diagnosis of dementia and
the development of preventive strategies. Neuropathology and structural MRI studies have …

Thyroid hormones play a critical role in the metabolic activity of the adult brain, and
neuropsychiatric manifestations of thyroid disease have long been recognised. However, it …

High fat diets and sedentary lifestyles are becoming major concerns for Western countries.
They have led to a growing incidence of obesity, dyslipidemia, high blood pressure, and a …

Over the past several years, there has been a surge in blood biomarker studies examining
the value of plasma or serum neurofilament light (NfL) as a biomarker of neurodegeneration …

Background: Few studies have compared the accuracy of [18F] fluorodeoxyglucose (FDG)
PET to the accuracy of clinical and pathologic diagnosis in dementia patients. Methods …

The neurovascular system (NVS), which consisted of neurons, glia, and vascular cells, is a
functional and structural unit of the brain. The NVS regulates blood-brain barrier (BBB) …

Alzheimer's disease is the most common cause of dementia in older adults. Although the
cognitive deficits and pathologic hallmarks of Alzheimer's disease have been well …

Patients with mild cognitive impairment (MCI) represent a risk population for progressing to
dementia of the Alzheimer type (DAT). However, clinical criteria do not ensure reliable …

Alzheimer's disease (AD) is the most common form of dementia. AD initially targets memory
and progressively destroys the mind. The brain atrophies as the neocortex suffers neuronal …