[HTML][HTML] The role of m6A RNA methylation in cancer
T Sun, R Wu, L Ming - Biomedicine & Pharmacotherapy, 2019 - Elsevier
Abstract N6-methyladenosine (m6A), the most abundant internal modification of RNA in
eukaryotic cells, has gained increasing attention in recent years. The m6A modification …
eukaryotic cells, has gained increasing attention in recent years. The m6A modification …
Mapping epigenetic modifications by sequencing technologies
The “epigenetics” concept was first described in 1942. Thus far, chemical modifications on
histones, DNA, and RNA have emerged as three important building blocks of epigenetic …
histones, DNA, and RNA have emerged as three important building blocks of epigenetic …
METTL3 preferentially enhances non-m6A translation of epigenetic factors and promotes tumourigenesis
X Wei, Y Huo, J Pi, Y Gao, S Rao, M He, Q Wei… - Nature cell …, 2022 - nature.com
METTL3 encodes the predominant catalytic enzyme to promote m6A methylation in nucleus.
Recently, accumulating evidence has shown the expression of METTL3 in cytoplasm, but its …
Recently, accumulating evidence has shown the expression of METTL3 in cytoplasm, but its …
METTL3 and ALKBH5 oppositely regulate m6A modification of TFEB mRNA, which dictates the fate of hypoxia/reoxygenation-treated cardiomyocytes
H Song, X Feng, H Zhang, Y Luo, J Huang, M Lin… - Autophagy, 2019 - Taylor & Francis
ABSTRACT N6-methyladenosine (m6A) mRNA modifications play critical roles in various
biological processes. However, no study addresses the role of m6A in macroautophagy …
biological processes. However, no study addresses the role of m6A in macroautophagy …
FTO plays an oncogenic role in acute myeloid leukemia as a N6-methyladenosine RNA demethylase
Summary N 6-Methyladenosine (m 6 A) represents the most prevalent internal modification
in mammalian mRNAs. Despite its functional importance in various fundamental …
in mammalian mRNAs. Despite its functional importance in various fundamental …
Upregulated METTL3 promotes metastasis of colorectal Cancer via miR-1246/SPRED2/MAPK signaling pathway
W Peng, J Li, R Chen, Q Gu, P Yang, W Qian… - Journal of Experimental …, 2019 - Springer
Background m6A modification has been proved to play an important role in many biological
processes. METTL3 as the main methyltransferase for methylation process has been found …
processes. METTL3 as the main methyltransferase for methylation process has been found …
The m6A methyltransferase METTL3 promotes bladder cancer progression via AFF4/NF-κB/MYC signaling network
M Cheng, L Sheng, Q Gao, Q Xiong, H Zhang, M Wu… - Oncogene, 2019 - nature.com
Abstract N 6-methyladenosine (m6A) is the most abundant modification in eukaryotic
messenger RNAs (mRNAs), and plays important roles in many bioprocesses. However, its …
messenger RNAs (mRNAs), and plays important roles in many bioprocesses. However, its …
[PDF][PDF] METTL14 suppresses the metastatic potential of hepatocellular carcinoma by modulating N6‐methyladenosine‐dependent primary MicroRNA processing
N6‐Methyladenosine (m6A) modification has been implicated in many biological processes.
However, its role in cancer has not been well studied. Here, we demonstrate that m6A …
However, its role in cancer has not been well studied. Here, we demonstrate that m6A …
HBXIP-elevated methyltransferase METTL3 promotes the progression of breast cancer via inhibiting tumor suppressor let-7g
Abstract Methyltransferase-like 3 (METTL3) is involved in RNA metabolism through N6-
methyladenosine (m 6 A) modification. However, whether METTL3 participates in the …
methyladenosine (m 6 A) modification. However, whether METTL3 participates in the …
Abnormality of m6A mRNA methylation is involved in Alzheimer's disease
M Han, Z Liu, Y Xu, X Liu, D Wang, F Li… - Frontiers in …, 2020 - frontiersin.org
Alzheimer's disease (AD), the most common form of dementia, is highly prevalent in older
adults. The main clinical feature is the progressive decline of memory function, which …
adults. The main clinical feature is the progressive decline of memory function, which …