Human diseases such as cancer can be caused by aberrant epigenetic regulation.
Polyphenols play a major role in mammalian epigenome regulation through mechanisms …

Acute myeloid leukaemia (AML) is a heterogeneous disease with one of the worst survival
rates of all cancers. The bone marrow microenvironment is increasingly being recognised as …

Genomic analyses have redefined the molecular subgrouping of pediatric acute
lymphoblastic leukemia (ALL). Molecular subgroups guide risk-stratification and targeted …

Physical activity impacts immune homeostasis and leads to rapid and marked increase in
cell-free DNA (cfDNA). However, the origin of cfDNA during exercise remains elusive and it …

Lymphoma is a common and aggressive form of hematopoietic malignancies with diverse
clinical and pathological features due to its heterogeneity. Although the current …

DNA methylation represents a crucial mechanism of epigenetic regulation in hematologic
malignancies. The methylation process is controlled by specific DNA methyl transferases …

ABL1 tyrosine kinase inhibitors (TKIs) dramatically improve the prognosis of chronic myeloid
leukemia (CML), but 10–20% of patients achieve suboptimal responses with low TKIs …

目的: 回顾性对比观察及分析地西他滨/阿扎胞苷分别联合HAAG (高三尖杉酯碱HTT,
阿糖胞苷Ara-C, 阿克拉霉素Acla 及重组人粒细胞集落刺激因子G-CSF) 治疗无法接受强化疗的 …

In a wide range of lymphoid neoplasms, the process of malignant transformation is
associated with somatic mutations in B cells that affect the epigenetic machinery …

Distinct DNA methylation signatures, related to different prognosis, have been observed
across many cancers, including T-cell acute lymphoblastic leukemia (T-ALL), an aggressive …