Does substance P act as a pain transmitter?
O Masanori, Y Mitsuhiko - Trends in Pharmacological Sciences, 1987 - cell.com
Pain signals appear to be transmitted by a variety of chemicals. Masanori Otsuka and
Mitsuhiko Yanagisawa review evidence that substance P, present in M-20% of primary …
Mitsuhiko Yanagisawa review evidence that substance P, present in M-20% of primary …
Pain and neurotransmitters
M Otsuka, M Yanagisawa - Cellular and molecular neurobiology, 1990 - Springer
To study physiological roles of substance P (SP), γ-aminobutyric acid (GABA), enkephalins
and other endogenous substances, we developed several kinds of isolated spinal cord …
and other endogenous substances, we developed several kinds of isolated spinal cord …
Selective antagonism of capsaicin by capsazepine: evidence for a spinal receptor site in capsaicin‐induced antinociception
AH Dickenson, A Dray - British journal of pharmacology, 1991 - Wiley Online Library
1 Capsazepine has recently been described as a competitive capsaicin antagonist. We have
used this compound to test the hypotheses that the in vitro and in vivo effects of capsaicin …
used this compound to test the hypotheses that the in vitro and in vivo effects of capsaicin …
Actions of capsaicin on peripheral nociceptors of the neonatal rat spinal cord‐tail in vitro: dependence of extracellular ions and independence of second messengers
A Dray, J Bettaney, P Forster - British journal of pharmacology, 1990 - Wiley Online Library
1 We have tested the hypothesis that capsaicin‐induced activation, desensitization and
impairment of peripheral nociceptor function is mediated by separate mechanisms. This was …
impairment of peripheral nociceptor function is mediated by separate mechanisms. This was …
Inhibitory effects of galanin on the isolated spinal cord of the newborn rat
M Yanagisawa, N Yagi, M Otsuka, C Yanaihara… - Neuroscience …, 1986 - Elsevier
The effects of galanin, a 29-amino-acid peptide, on spinal reflexes were studied. In the
isolated hemisected spinal cord of the newborn rat, galanin (0.1–5 μM) depressed the …
isolated hemisected spinal cord of the newborn rat, galanin (0.1–5 μM) depressed the …
Facilitation of the tail-flick reflex by noxious cutaneous stimulation in the rat: antagonism by a substance P analogue
RA Cridland, JL Henry - Brain research, 1988 - Elsevier
Abstract Effects of noxious cutaneous stimulation on the tail flick reflex were examined in the
anaesthetized rat. Noxious stimulation was applied by immersing the distal 4 cm of the tail in …
anaesthetized rat. Noxious stimulation was applied by immersing the distal 4 cm of the tail in …
A spinal mechanism of action is involved in the antinociception produced by the capsaicin analogue NE 19550 (olvanil)
A Dickenson, C Hughes, A Rueff, A Dray - Pain, 1990 - journals.lww.com
We have studied the effect of NE 19550 (olvanil, N-(4-hydroxy-3-methoxyphenyl) methyl-9Z-
octadecenamide), a capsaicin analogue with approximately equipotent antinociceptive …
octadecenamide), a capsaicin analogue with approximately equipotent antinociceptive …
The pharmacology of segmental transmission in the spinal cord
RH Evans - Progress in neurobiology, 1989 - Elsevier
3.2. Tachykinin antagonists 3.3. Association of long duration synaptic excitation and C fibre
primary afferent input 3.4. Excitatory amino acid as C fibre transmitters 3.5. Capsaicin as a …
primary afferent input 3.4. Excitatory amino acid as C fibre transmitters 3.5. Capsaicin as a …
Sensory innervation of reproductive organs
T Kumazawa - Progress in brain research, 1986 - Elsevier
Publisher Summary Development of the reproductive organs is quite complicated, for they
involve tissues originating from the cranial as well as the caudal region of the abdominal …
involve tissues originating from the cranial as well as the caudal region of the abdominal …
E-type prostaglandins depolarize primary afferent neurons of the neonatal rat
M Yanagisawa, M Otsuka, JE García-Arrarás - Neuroscience letters, 1986 - Elsevier
The mechanism of action of prostanglandins (PGs) to sensitize sensory terminals to noxious
stimuli was studied in the isolated spinal cord-tail preparation of the newborn rat. Application …
stimuli was studied in the isolated spinal cord-tail preparation of the newborn rat. Application …