Pain signals appear to be transmitted by a variety of chemicals. Masanori Otsuka and
Mitsuhiko Yanagisawa review evidence that substance P, present in M-20% of primary …

To study physiological roles of substance P (SP), γ-aminobutyric acid (GABA), enkephalins
and other endogenous substances, we developed several kinds of isolated spinal cord …

1 Capsazepine has recently been described as a competitive capsaicin antagonist. We have
used this compound to test the hypotheses that the in vitro and in vivo effects of capsaicin …

1 We have tested the hypothesis that capsaicin‐induced activation, desensitization and
impairment of peripheral nociceptor function is mediated by separate mechanisms. This was …

The effects of galanin, a 29-amino-acid peptide, on spinal reflexes were studied. In the
isolated hemisected spinal cord of the newborn rat, galanin (0.1–5 μM) depressed the …

Abstract Effects of noxious cutaneous stimulation on the tail flick reflex were examined in the
anaesthetized rat. Noxious stimulation was applied by immersing the distal 4 cm of the tail in …

We have studied the effect of NE 19550 (olvanil, N-(4-hydroxy-3-methoxyphenyl) methyl-9Z-
octadecenamide), a capsaicin analogue with approximately equipotent antinociceptive …

3.2. Tachykinin antagonists 3.3. Association of long duration synaptic excitation and C fibre
primary afferent input 3.4. Excitatory amino acid as C fibre transmitters 3.5. Capsaicin as a …

Publisher Summary Development of the reproductive organs is quite complicated, for they
involve tissues originating from the cranial as well as the caudal region of the abdominal …

The mechanism of action of prostanglandins (PGs) to sensitize sensory terminals to noxious
stimuli was studied in the isolated spinal cord-tail preparation of the newborn rat. Application …