Mesenchymal stem cell secretome: toward cell-free therapeutic strategies in regenerative medicine

FJ Vizoso, N Eiro, S Cid, J Schneider… - International journal of …, 2017 - mdpi.com
Earlier research primarily attributed the effects of mesenchymal stem cell (MSC) therapies to
their capacity for local engrafting and differentiating into multiple tissue types. However …

Prospect of stem cell conditioned medium in regenerative medicine

JA Pawitan - BioMed research international, 2014 - Wiley Online Library
Background. Stem cell‐derived conditioned medium has a promising prospect to be
produced as pharmaceuticals for regenerative medicine. Objective. To investigate various …

[PDF][PDF] Amino acid restriction triggers angiogenesis via GCN2/ATF4 regulation of VEGF and H2S production

A Longchamp, T Mirabella, A Arduini, MR MacArthur… - Cell, 2018 - cell.com
Angiogenesis, the formation of new blood vessels by endothelial cells (ECs), is an adaptive
response to oxygen/nutrient deprivation orchestrated by vascular endothelial growth factor …

Bioprinted amniotic fluid-derived stem cells accelerate healing of large skin wounds

A Skardal, D Mack, E Kapetanovic… - Stem cells …, 2012 - academic.oup.com
Stem cells obtained from amniotic fluid show high proliferative capacity in culture and
multilineage differentiation potential. Because of the lack of significant immunogenicity and …

Applications of the amniotic membrane in tissue engineering and regeneration: the hundred-year challenge

H Elkhenany, A El-Derby, M Abd Elkodous… - Stem Cell Research & …, 2022 - Springer
The amniotic membrane (Amnio-M) has various applications in regenerative medicine. It
acts as a highly biocompatible natural scaffold and as a source of several types of stem cells …

[HTML][HTML] Mesenchymal stromal cells and their secretome: new therapeutic perspectives for skeletal muscle regeneration

M Sandonà, L Di Pietro, F Esposito… - … in bioengineering and …, 2021 - frontiersin.org
Mesenchymal stromal cells (MSCs) are multipotent cells found in different tissues: bone
marrow, peripheral blood, adipose tissues, skeletal muscle, perinatal tissues, and dental …

[HTML][HTML] Decellularized matrices for cardiovascular tissue engineering

F Moroni, T Mirabella - American journal of stem cells, 2014 - ncbi.nlm.nih.gov
Cardiovascular disease (CVD) is one of the leading causes of death in the Western world.
The replacement of damaged vessels and valves has been practiced since the 1950's …

Concise review: amniotic fluid stem cells: the known, the unknown, and potential regenerative medicine applications

SP Loukogeorgakis, P De Coppi - Stem Cells, 2017 - academic.oup.com
The amniotic fluid has been identified as an untapped source of cells with broad potential,
which possess immunomodulatory properties and do not have the ethical and legal …

3D-printed vascular networks direct therapeutic angiogenesis in ischaemia

T Mirabella, JW MacArthur, D Cheng… - Nature biomedical …, 2017 - nature.com
Arterial bypass grafts remain the gold standard for the treatment of end-stage ischaemic
disease. Yet patients unable to tolerate the cardiovascular stress of arterial surgery or those …

First characterization of human amniotic fluid stem cell extracellular vesicles as a powerful paracrine tool endowed with regenerative potential

C Balbi, M Piccoli, L Barile, A Papait… - Stem cells …, 2017 - academic.oup.com
Human amniotic fluid stem cells (hAFS) have shown a distinct secretory profile and
significant regenerative potential in several preclinical models of disease. Nevertheless, little …