Synthesis, biological evaluation, and molecular docking of novel azolylhydrazonothiazoles as potential anticancer agents

JY Al-Humaidi, SM Gomha, SM Riyadh, MS Ibrahim… - ACS …, 2023 - ACS Publications
A novel set of thiazolylhydrazonothiazoles bearing an indole moiety were synthesized by
subjection reactions of carbothioamide derivative and hydrazonoyl chlorides (or α …

Synthesis, in vitro evaluation and molecular docking studies of novel thiophenyl thiazolyl-pyridine hybrids as potential anticancer agents

FO Ashmawy, SM Gomha, MA Abdallah, MEA Zaki… - Molecules, 2023 - mdpi.com
Many literature reports revealed the anticancer activity of pyridine and thiazole derivatives,
especially in lung cancer. Therefore, a new series of thiazolyl pyridines linked with …

Synthesis, molecular docking study, and cytotoxic activity against MCF cells of new Thiazole–Thiophene scaffolds

SM Gomha, SM Riyadh, B Huwaimel, MEM Zayed… - Molecules, 2022 - mdpi.com
Investigating novel compounds that may be useful in designing new, less toxic, selective,
and potent breast anticancer agents is still the main challenge for medicinal chemists. Thus …

[HTML][HTML] Synthesis, in-silico studies, and biological evaluation of some novel 3-thiazolyl-indoles as CDK2–inhibitors

SM Gomha, MEA Zaki, D Maliwal, RRS Pissurlenkar… - Results in …, 2023 - Elsevier
The essential enzyme cyclin-dependent kinase 2 (CDK2) is a promising target for anticancer
drug development due to its pivotal role in regulating the cell cycle. This study aimed to …

A novel of azo-thiazole moiety alternative for benzidine-based pigments: design, synthesis, characterization, biological evaluation, and molecular docking study

HF Rizk, MA El-Borai, A Ragab… - Polycyclic Aromatic …, 2023 - Taylor & Francis
A new series of coloring compounds (pigments) based on 5-(2-aminothiazol-5-yl) thiazol-2-
amine and 5-(4-aminophenyl) thiazol-2-amine as heterocyclic alternatives for benzidine …

[HTML][HTML] Synthesis, molecular docking study, and biological evaluation and of new thiadiazole and thiazole derivatives incorporating isoindoline-1, 3-dione moiety as …

WA Mokbel, MA Hosny, SM Gomha, MEA Zaki… - Results in …, 2024 - Elsevier
To highlight the importance of thiazole and thiadiazole derivatives in the progression of
cancer and microbial treatments and to aid in drug design, we have synthesized a new …

Designing metal chelates of halogenated sulfonamide Schiff bases as potent nonplatinum anticancer drugs using spectroscopic, molecular docking and biological …

RMI Elsamra, MS Masoud, AM Ramadan - Scientific Reports, 2022 - nature.com
In this contribution, five Ni (II) complexes have been synthesized from sulfonamide-based
Schiff bases (SB1–SB5) that comprise bromo or iodo substituents in the salicylidene moiety …

Synthesis, Physicochemical Characterization, Biological Assessment, and Molecular Docking Study of Some Metal Complexes of Alloxan and Ninhydrin as …

MS Masoud, GA Yacout, BA Abd-El-Khalek… - Journal of Inorganic and …, 2023 - Springer
A series of transition metal complexes of alloxan monohydrate (H2L1) and ninhydrin (H2L2)
have been prepared where metal ions are Fe (III), Co (II), Ni (II), Cu (II), Zr (IV), and Mo (VI) …

Therapeutic potential of phospho-thiadiazole derivatives as anti-glioblastoma agents: synthesis, biological assessment and computational study

K Gholivand, M Faraghi, N Fallah, A Babaei… - Bioorganic …, 2022 - Elsevier
In this study, three new phospho thiadiazole compounds (A, F and W) were investigated as
possible cytotoxic agents. The compounds were synthesised and characterised by using …

Advances in the Synthesis of Heterocycles with Two and Three Heteroatoms using Hydrazonoyl Halides

NR Yamaletdinova, RR Gataullin - Helvetica Chimica Acta, 2024 - Wiley Online Library
The review covers the results of studies published in the literature on the use of hydrazonoyl
halides in the synthesis of five‐(pyrazoles, thiazoles, triazoles, oxa‐and thiadiazoles), six …