Regardless of the cause, symptomatic heart failure (HF) with reduced ejection fraction (rEF)
is characterized by pathological activation of the renin–angiotensin–aldosterone system …

The renin-angiotensin-aldosterone system (RAAS) plays a key role in the pathophysiology
of arterial hypertension as well as in more complex mechanisms of cardiovascular and renal …

Cardiovascular disease (CVD) is the main public health problem in patients with chronic
kidney disease (CKD); however, there is no established biomarker for predicting CVD …

Heart failure is common in adult population, accounting for substantial morbidity and
mortality worldwide. The main risk factors for heart failure are coronary artery disease …

Drugs which interact with the renin angiotensin aldosterone system (RAAS) aim to reduce
the negative effects of angiotensin (Ang) II. Treatment with these drugs anticipate a …

The aim of this study was to assess any potential additive effects of a treatment combining
aliskiren with paricalcitol on reducing renal fibrosis. C57BL/6J mice were treated individually …

Bipolar Disorder (BD) is a chronic a multifactorial psychiatric illness that affects mood,
cognition, and functioning. BD is associated with several psychiatric conditions as well …

Background The association of renin with adverse kidney outcomes is largely unknown, and
renin measurement strategies vary. We aimed to measure the clinical correlates of different …

Hypertension (HTN) is the single most important cause of cardiovascular mortality and
morbidity worldwide. Nearly 45% of all cardiovascular and 51% of stroke deaths are due to …

BACKGROUND About one-half of all hypertensive adults do not have their blood pressure
controlled. They are often prescribed medications that conform to national guidelines but …