[HTML][HTML] The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology

A Rutsch, JB Kantsjö, F Ronchi - Frontiers in immunology, 2020 - frontiersin.org
The human microbiota has a fundamental role in host physiology and pathology. Gut
microbial alteration, also known as dysbiosis, is a condition associated not only with …

[HTML][HTML] Molecular mimicry and autoimmunity

M Rojas, P Restrepo-Jiménez, DM Monsalve… - Journal of …, 2018 - Elsevier
Molecular mimicry is one of the leading mechanisms by which infectious or chemical agents
may induce autoimmunity. It occurs when similarities between foreign and self-peptides …

[HTML][HTML] Tissue-specific Tregs in cancer metastasis: opportunities for precision immunotherapy

LA Huppert, MD Green, L Kim, C Chow… - Cellular & molecular …, 2022 - nature.com
Decades of advancements in immuno-oncology have enabled the development of current
immunotherapies, which provide long-term treatment responses in certain metastatic cancer …

[HTML][HTML] Inflammatory role of TLR-MyD88 signaling in multiple sclerosis

C Zheng, J Chen, F Chu, J Zhu, T Jin - Frontiers in molecular …, 2020 - frontiersin.org
Multiple sclerosis (MS) is a neuro-autoimmune and neurodegenerative disorder leading to
chronic inflammation, demyelination, axonal, and neuronal loss in the central nervous …

[HTML][HTML] Molecular mechanisms of drug resistance in glioblastoma

MA Dymova, EV Kuligina, VA Richter - International journal of molecular …, 2021 - mdpi.com
Glioblastoma multiforme (GBM) is the most common and fatal primary brain tumor, is highly
resistant to conventional radiation and chemotherapy, and is not amenable to effective …

[HTML][HTML] HIV infection of non-classical cells in the brain

A Wahl, L Al-Harthi - Retrovirology, 2023 - Springer
HIV-associated neurological disorders (HAND) affect up to 50% of people living with HIV
(PLWH), even in the era of combination antiretroviral therapy (cART). HIV-DNA can be …

Lung-brain axis

O Bajinka, L Simbilyabo, Y Tan, J Jabang… - Critical reviews in …, 2022 - Taylor & Francis
The appreciation of human microbiome is gaining strong grounds in biomedical research. In
addition to gut-brain axis, is the lung-brain axis, which is hypothesised to link pulmonary …

Toll-like receptor-mediated neuroinflammation: relevance for cognitive dysfunctions

S Squillace, D Salvemini - Trends in pharmacological sciences, 2022 - cell.com
Toll-like receptors (TLRs) are pattern recognition receptors (PRRs) with a well-documented
role in the innate and adaptive immune responses. Interestingly, TLR activation has also …

[HTML][HTML] Glioblastoma organoids: pre-clinical applications and challenges in the context of immunotherapy

E Klein, AC Hau, A Oudin, A Golebiewska… - Frontiers in …, 2020 - frontiersin.org
Malignant brain tumors remain uniformly fatal, even with the best-to-date treatment. For
Glioblastoma (GBM), the most severe form of brain cancer in adults, the median overall …

[HTML][HTML] Unveiling the gut-brain axis: structural and functional analogies between the gut and the choroid plexus vascular and immune barriers

S Carloni, M Rescigno - Seminars in Immunopathology, 2022 - Springer
The vasculature plays an essential role in the development and maintenance of blood-tissue
interface homeostasis. Knowledge on the morphological and functional nature of the blood …