The inflammasome is a macromolecular protein complex that mediates proteolytic cleavage
of pro-IL-1β and-IL-18 and induces cell death in the form of pyroptosis. Certain nucleotide …

Innate lymphoid cells (ILCs) reside in mucosal surfaces to potentiate immune responses,
sustain mucosal integrity and maintain tissue homeostasis. However, how tumor infiltrating …

Pyroptosis, a type of inflammatory programmed cell death, is mediated by multiple
inflammasomes which can recognize danger signals and activate the secretion of pro …

Chemotherapies are known often to induce severe gastrointestinal tract toxicity but the
underlying mechanism remains unclear. This study considers the widely applied cytotoxic …

NLRs (nucleotide-binding domain and leucine-rich repeats) belong to a large family of
cytoplasmic sensors that regulate an extraordinarily diverse range of biological functions …

Inflammatory bowel diseases (IBD) affect over 5 million individuals in the industrialized
world, with an increasing incidence rate worldwide. IBD also predisposes affected …

Revolutionary advancements of high-throughput sequencing and metagenomic tools have
provided new insights to microbiome function, including a bidirectional relationship between …

The immune system has evolved to protect the host from the pathogens and allergens
surrounding their environment. The immune system develops in such a way to recognize …

Intestinal microbiota have emerged as an important factor in colorectal cancer (CRC)
initiation and progression. The currently prominent view on bacterial tumorigenesis is that …

Inflammasomes are important for maintaining intestinal homeostasis, and dysbiosis
contributes to the pathology of inflammatory bowel disease (IBD) and increases the risk for …