The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis

K Dheda, T Gumbo, G Maartens, KE Dooley… - The lancet Respiratory …, 2017 - thelancet.com
Global tuberculosis incidence has declined marginally over the past decade, and
tuberculosis remains out of control in several parts of the world including Africa and Asia …

[HTML][HTML] Bacterial genome sequencing in clinical microbiology: a pathogen-oriented review

F Tagini, G Greub - European journal of clinical microbiology & infectious …, 2017 - Springer
In recent years, whole-genome sequencing (WGS) has been perceived as a technology with
the potential to revolutionise clinical microbiology. Herein, we reviewed the literature on the …

Same-day diagnostic and surveillance data for tuberculosis via whole-genome sequencing of direct respiratory samples

AA Votintseva, P Bradley, L Pankhurst… - Journal of clinical …, 2017 - Am Soc Microbiol
Routine full characterization of Mycobacterium tuberculosis is culture based, taking many
weeks. Whole-genome sequencing (WGS) can generate antibiotic susceptibility profiles to …

[HTML][HTML] Genomic characterization of nontuberculous mycobacteria

T Fedrizzi, CJ Meehan, A Grottola, E Giacobazzi… - Scientific reports, 2017 - nature.com
Mycobacterium tuberculosis and Mycobacterium leprae have remained, for many years, the
primary species of the genus Mycobacterium of clinical and microbiological interest. The …

[HTML][HTML] High-resolution mapping of tuberculosis transmission: Whole genome sequencing and phylogenetic modelling of a cohort from Valencia Region, Spain

Y Xu, I Cancino-Muñoz, M Torres-Puente… - PLoS …, 2019 - journals.plos.org
Background Whole genome sequencing provides better delineation of transmission clusters
in Mycobacterium tuberculosis than traditional methods. However, its ability to reveal …

[HTML][HTML] Interpreting whole genome sequencing for investigating tuberculosis transmission: a systematic review

HA Hatherell, C Colijn, HR Stagg, C Jackson… - BMC medicine, 2016 - Springer
Background Whole genome sequencing (WGS) is becoming an important part of
epidemiological investigations of infectious diseases due to greater resolution and cost …

[HTML][HTML] Mycobacterium tuberculosis and whole-genome sequencing: how close are we to unleashing its full potential?

G Satta, M Lipman, GP Smith, C Arnold, OM Kon… - Clinical Microbiology …, 2018 - Elsevier
Background Nearly two decades after completion of the genome sequence of
Mycobacterium tuberculosis (MTB), and with the advent of next generation sequencing …

Comprehensive whole-genome sequencing and reporting of drug resistance profiles on clinical cases of Mycobacterium tuberculosis in New York State

J Shea, TA Halse, P Lapierre, M Shudt… - Journal of clinical …, 2017 - Am Soc Microbiol
Whole-genome sequencing (WGS) is a newer alternative for tuberculosis (TB) diagnostics
and is capable of providing rapid drug resistance profiles while performing species …

Standard genotyping overestimates transmission of Mycobacterium tuberculosis among immigrants in a low-incidence country

D Stucki, M Ballif, M Egger, H Furrer… - Journal of clinical …, 2016 - Am Soc Microbiol
Immigrants from regions with a high incidence of tuberculosis (TB) are a risk group for TB in
low-incidence countries such as Switzerland. In a previous analysis of a nationwide …

[HTML][HTML] A quantitative evaluation of MIRU-VNTR typing against whole-genome sequencing for identifying Mycobacterium tuberculosis transmission: a prospective …

DH Wyllie, JA Davidson, EG Smith, P Rathod… - …, 2018 - thelancet.com
Abstract Background Mycobacterial Interspersed Repetitive Unit-Variable Number Tandem
Repeat (MIRU-VNTR) typing is widely used in high-income countries to determine …