Glioblastoma (GBM) is one of the most prevalent malignant brain tumors with poor
prognosis. Increasing evidence has revealed that infiltrating immune cells and other stromal …

Pancreatic cancer (PC) is a highly lethal malignancy with a 5-year survival rate of 10%. The
occurrence of metastasis, among other hallmarks, is the main contributor to its poor …

Plasminogen activator, urokinase (uPA) is a secreted serine protease whose Dysregulation
is often accompanied by various cancers. However, the biological functions and potential …

Background: Gastric cancer (GC) is the fifth most frequently diagnosed malignancy, and the
third leading cause of tumor-related mortalities worldwide. Due to a high heterogeneity in …

Cancer-associated fibroblasts (CAFs) influence many aspects of pancreatic
adenocarcinoma (PAAD) carcinogenesis, including tumor cell proliferation, angiogenesis …

Tongue squamous cell carcinoma (TSCC), one of the most frequent cancers of the oral
cavity, owns unsatisfactory survival even combining treatments involving surgery …

Accumulating evidence revealed that autophagy played vital roles in breast cancer (BC)
progression. Thus, the aim of this study was to investigate the prognostic value of autophagy …

Osteogenic activity of vitamin K2 (VK2), a small molecular nutrient, has been suggested.
However, the underlying mechanisms have not been fully elucidated. Therefore, this study …

Background Testicular cancer severely affects male health, so finding effective diagnosis
and prognostic indicators and exploring its pathogenesis are very important. Purpose This …

Background Sepsis is a life-threatening multi-organ dysfunction caused by the dysregulated
host response to infection. Sepsis remains a major global concern with high mortality and …