[HTML][HTML] The arrival of anti-CGRP monoclonal antibodies in migraine
Remarkable advancements have been made in the field of migraine pathophysiology and
pharmacotherapy over the past decade. Understanding the molecular mechanism of …
pharmacotherapy over the past decade. Understanding the molecular mechanism of …
[HTML][HTML] Going Too Far Is the Same as Falling Short†: Kinesin-3 Family Members in Hereditary Spastic Paraplegia
Proper intracellular trafficking is essential for neuronal development and function, and when
any aspect of this process is dysregulated, the resulting “transportopathy” causes …
any aspect of this process is dysregulated, the resulting “transportopathy” causes …
[HTML][HTML] Neuropeptides and behaviors: how small peptides regulate nervous system function and behavioral outputs
One of the reasons that most multicellular animals survive and thrive is because of the
adaptable and plastic nature of their nervous systems. For an organism to survive, it is …
adaptable and plastic nature of their nervous systems. For an organism to survive, it is …
Tear film and ocular surface neuropeptides: Characteristics, synthesis, signaling and implications for ocular surface and systemic diseases
Ocular surface neuropeptides are vital molecules primarily involved in maintaining ocular
surface integrity and homeostasis. They also serve as communication channels between the …
surface integrity and homeostasis. They also serve as communication channels between the …
PACAP induces light aversion in mice by an inheritable mechanism independent of CGRP
A Kuburas, BN Mason, B Hing, AS Wattiez… - Journal of …, 2021 - Soc Neuroscience
The neuropeptides CGRP (calcitonin gene-related peptide) and PACAP (pituitary adenylate
cyclase-activating polypeptide) have emerged as mediators of migraine, yet the potential …
cyclase-activating polypeptide) have emerged as mediators of migraine, yet the potential …
The premetazoan ancestry of the synaptic toolkit and appearance of first neurons
J Colgren, P Burkhardt - Essays in Biochemistry, 2022 - portlandpress.com
Neurons, especially when coupled with muscles, allow animals to interact with and navigate
through their environment in ways unique to life on earth. Found in all major animal lineages …
through their environment in ways unique to life on earth. Found in all major animal lineages …
CGRP monoclonal antibodies for migraine: rationale and progress
Calcitonin gene-related peptide (CGRP), a neuropeptide abundant in the trigeminal system
and widely expressed in both the peripheral and central nervous systems, has recently …
and widely expressed in both the peripheral and central nervous systems, has recently …
Sleep disturbance and Alzheimer's disease: the glial connection
A Sunkaria, S Bhardwaj - Neurochemical Research, 2022 - Springer
Poor quality and quantity of sleep are very common in elderly people throughout the world.
Growing evidence has suggested that sleep disturbances could accelerate the process of …
Growing evidence has suggested that sleep disturbances could accelerate the process of …
Extracellular vesicles and the Stress System
EA Makrygianni, GP Chrousos - Neuroendocrinology, 2023 - karger.com
Extracellular vesicles (EVs) are membrane-enclosed nanoparticles that contain various
biomolecules, including nucleic acids, proteins and lipids, and are manufactured and …
biomolecules, including nucleic acids, proteins and lipids, and are manufactured and …
Transition metal ions and neurotransmitters: coordination chemistry and implications for neurodegeneration
Neurodegeneration is characterized by a disturbance in neurotransmitter-mediated
signaling pathways. Recent studies have highlighted the significant role of transition metal …
signaling pathways. Recent studies have highlighted the significant role of transition metal …