A wealth of neuromodulatory transmitters regulate synaptic circuits in the brain. Their mode
of signaling, often called volume transmission, differs from classical synaptic transmission in …

The mammalian circadian system is composed of a central clock situated in the
hypothalamic suprachiasmatic nucleus (SCN) and peripheral clocks of each tissue and …

The endogenous opioid peptide system, comprised of enkephalins, endorphins, dynorphins,
and nociceptin, is a highly complex neurobiological system. Opioid peptides are derived …

Glycosylated neuropeptides were recently discovered in crustaceans, a model organism
with a well‐characterized neuroendocrine system. Several workflows exist to characterize …

Neuropathic ocular pain is a frequent occurrence in medium to severe dry eye disease
(DED). Only palliative treatments, such as lubricants and anti-inflammatory drugs, are …

Extra-synaptic exocytosis is an essential component of cellular communication. A
knowledge gap exists in the exocytosis of the non-redox active transmitter acetylcholine …

Neuropeptides regulate animal physiology and behavior, making them widely studied
targets of functional genetics research. While the field often relies on differential-omics …

Antimicrobial peptides (AMPs) are classically known as important effector molecules in
innate immunity across all multicellular organisms. However, emerging evidence begins to …

The development of novel pain therapeutics hinges on the identification and rigorous
validation of potential targets. Model organisms provide a means to test the involvement of …

Neuropeptides are bioactive molecules, made up of small chains of amino acids, with many
neuromodulatory properties. Several lines of evidence suggest that neuropeptides, mainly …