Parkinson's disease (PD) is a common neurodegenerative disorder primarily characterized
by the death of dopaminergic neurons that project from the substantia nigra pars compacta …

Neuronal cell death occurs extensively during development and pathology, where it is
especially important because of the limited capacity of adult neurons to proliferate or be …

The pro-inflammatory immune response driven by microglia is a key contributor to the
pathogenesis of several neurodegenerative diseases. Though the research of microglia …

There is growing evidence that excessive microglial phagocytosis of neurons and synapses
contributes to multiple brain pathologies. RNA‐seq and genome‐wide association (GWAS) …

The endotoxin hypothesis of neurodegeneration is the hypothesis that endotoxin causes or
contributes to neurodegeneration. Endotoxin is a lipopolysaccharide (LPS), constituting …

Traditionally, lymphocytic interferon γ (IFN-γ) was considered to be a simple'booster'of
proinflammatory responses by microglia (brain-resident macrophages) during bacterial or …

Increasing evidence suggests that Alzheimer's disease pathogenesis is not restricted to the
neuronal compartment, but includes strong interactions with immunological mechanisms in …

Microglia are the predominant immune cells of the central nervous system (CNS) that exert
key physiological roles required for maintaining CNS homeostasis, notably in response to …

Reactive oxygen and nitrogen species (ROS/RNS) are generated by macrophages inside
their phagolysosomes. This production is essential for phagocytosis of damaged cells and …

Neuroinflammation is central to the common pathology of several acute and chronic brain
diseases. This review examines the consequences of excessive and prolonged …