The muscular dystrophies are inherited myogenic disorders characterised by progressive
muscle wasting and weakness of variable distribution and severity. They can be subdivided …

The X-linked muscle-wasting disease Duchenne muscular dystrophy is caused by mutations
in the gene encoding dystrophin. There is currently no effective treatment for the disease; …

Chronic inflammation and fibrosis characterize Duchenne muscular dystrophy (DMD). We
show that pro-inflammatory macrophages are associated with fibrosis in mouse and human …

Muscular dystrophy includes a diverse group of inherited muscle diseases characterized by
wasting and weakness of skeletal muscle. Mutations in dysferlin are linked to two clinically …

The dystrophin glycoprotein complex (DGC) is a specialization of cardiac and skeletal
muscle membrane. This large multicomponent complex has both mechanical stabilizing and …

▪ Abstract Striated muscle is an intricate, efficient, and precise machine that contains
complex interconnected cytoskeletal networks critical for its contractile activity. The …

α-and β-dystroglycan constitute a membrane-spanning complex that connects the
extracellular matrix to the cytoskeleton. Although a structural role for dystroglycan had been …

Mesoangioblasts are stem/progenitor cells derived from a subset of pericytes found in
muscle that express alkaline phosphatase. They have been shown to ameliorate the …

Preclinical or clinical trials for muscular dystrophies have met with modest success, mainly
because of inefficient delivery of viral vectors or donor cells to dystrophic muscles. We report …

Muscular dystrophies represent a heterogeneous group of disorders, which have been
largely classified by clinical phenotype. In the last 10 years, identification of novel skeletal …