Eukaryotic cells have been confronted throughout their evolution with potentially lethal
plasma membrane injuries, including those caused by osmotic stress, by infection from …

Membrane trafficking pathways are essential for the viability and growth of cells, and play a
major role in the interaction of cells with their environment. In this At a Glance article and …

A myoferlin gain-of-function variant associates with a new type of hereditary angioedema A
myoferlin gain-of-function variant associates with a new type of hereditary angioedema …

The muscular dystrophies comprise more than 30 clinical disorders that are characterized by
progressive skeletal muscle wasting and degeneration. Although the genetic basis for many …

One of the hallmarks of the parasitic phylum of Apicomplexa is the presence of highly
specialised, apical secretory organelles, called the micronemes and rhoptries that play …

Hearing relies on rapid, temporally precise, and sustained neurotransmitter release at the
ribbon synapses of sensory cells, the inner hair cells (IHCs). This process requires otoferlin …

Lysosomes must maintain the integrity of their limiting membrane to ensure efficient fusion
with incoming organelles and degradation of substrates within their lumen. Pancreatic …

Sound is encoded at synapses between cochlear inner hair cells and the auditory nerve.
These synapses are anatomically and functionally specialized to transmit acoustic …

Transverse (T)-tubules make-up a specialized network of tubulated muscle cell membranes
involved in excitation-contraction coupling for power of contraction. Little is known about …

Extended synaptotagmins (E-Syts) mediate lipid exchange between the endoplasmic
reticulum (ER) and the plasma membrane (PM). Anchored on the ER, E-Syts bind the PM via …