Paraventricular nucleus projections to the nucleus tractus solitarii are essential for full expression of hypoxia‐induced peripheral chemoreflex responses

BC Ruyle, L Lima‐Silveira, D Martinez… - The Journal of …, 2023 - Wiley Online Library
The hypothalamic paraventricular nucleus (PVN) is essential to peripheral chemoreflex
neurocircuitry, but the specific efferent pathways utilized are not well defined. The PVN …

Unilateral vagotomy alters astrocyte and microglial morphology in the nucleus tractus solitarii of the rat

GC Hofmann, EM Hasser… - American Journal of …, 2021 - journals.physiology.org
The nucleus tractus solitarii (nTS) is the initial site of integration of sensory information from
the cardiorespiratory system and contributes to reflex responses to hypoxia. Afferent fibers of …

Nucleus tractus solitarii is required for the development and maintenance of phrenic and sympathetic long-term facilitation after acute intermittent hypoxia

D Ostrowski, CM Heesch, DD Kline… - Frontiers in …, 2023 - frontiersin.org
Exposure to acute intermittent hypoxia (AIH) induces prolonged increases (long term
facilitation, LTF) in phrenic and sympathetic nerve activity (PhrNA, SNA) under basal …

Cardiovascular deconditioning increases GABA signaling in the nucleus tractus solitarii

L Lima-Silveira, EM Hasser… - Journal of …, 2022 - journals.physiology.org
The nucleus tractus solitarii (nTS) is the major integrative brainstem region for autonomic
modulation and processing of cardiovascular reflexes. GABA and glutamate are the main …

Kv2 channels contribute to neuronal activity within the vagal afferent-nTS reflex arc

A Ramirez-Navarro, L Lima-Silveira… - … of Physiology-Cell …, 2024 - journals.physiology.org
Diversity in the functional expression of ion channels contributes to the unique patterns of
activity generated in visceral sensory A-type myelinated neurons versus C-type …

Enhancement of the Evoked Excitatory Transmission in the Nucleus Tractus Solitarius Neurons after Sustained Hypoxia in Mice Depends on A2A Receptors

JR Souza, L Lima-Silveira, D Accorsi-Mendonça… - Neuroscience, 2024 - Elsevier
The first synapses of the afferents of peripheral chemoreceptors are located in the Nucleus
Tractus Solitarius (NTS) and there is evidence that short-term sustained hypoxia (SH–24 h …

Oxytocin and corticotropin‐releasing hormone exaggerate nucleus tractus solitarii neuronal and synaptic activity following chronic intermittent hypoxia

P Gama de Barcellos Filho, HA Dantzler… - The Journal of …, 2024 - Wiley Online Library
Chronic intermittent hypoxia (CIH) in rodents mimics the hypoxia‐induced elevation of blood
pressure seen in individuals experiencing episodic breathing. The brainstem nucleus tractus …

Vagotomy blunts cardiorespiratory responses to vagal afferent stimulation via pre‐and postsynaptic effects in the nucleus tractus solitarii

GC Hofmann, P Gama de Barcellos Filho… - The Journal of …, 2024 - Wiley Online Library
Viscerosensory information travels to the brain via vagal afferents, where it is first integrated
within the brainstem nucleus tractus solitarii (nTS), a critical contributor to cardiorespiratory …

Chronic vagotomy induces nTS glial activation, reduced glutamatergic signaling, and blunted cardiorespiratory responses

GC Hofmann - 2024 - mospace.umsystem.edu
The brainstem nucleus tractus solitarii (nTS) is the first site of integration of viscerosensory
information provided by afferents of the vagus nerves. The nTS critically contributes to …