A systematic and robust assessment of hot-melt extrusion-based amorphous solid dispersions: Theoretical prediction to practical implementation

A Alzahrani, D Nyavanandi, P Mandati… - International Journal of …, 2022 - Elsevier
Amorphous solid dispersions (ASDs) have gained attention as a formulation strategy in
recent years, with the potential to improve the apparent solubility and, hence, the oral …

Crystallinity: a complex critical quality attribute of amorphous solid dispersions

DE Moseson, LS Taylor - Molecular Pharmaceutics, 2023 - ACS Publications
Does the performance of an amorphous solid dispersion rely on having 100% amorphous
content? What specifications are appropriate for crystalline content within an amorphous …

Transition Metal-Decorated B12N12–X (X = Au, Cu, Ni, Os, Pt, and Zn) Nanoclusters as Biosensors for Carboplatin

I Benjamin, H Louis, GA Okon, SW Qader… - ACS …, 2023 - ACS Publications
Theoretical studies on the adsorption, sensibility, and reactivity of a boron nitride nanocage
decorated with Au, Cu, Ni, Os, Pt, and Zn metals as a biosensor material were carried out for …

Strategies to improve the stability of amorphous solid dispersions in view of the hot melt extrusion (HME) method

ALJ Khater, SH Almurisi, S Mahmood… - International Journal of …, 2023 - Elsevier
Oral administration of drugs is preferred over other routes for several reasons: it is non-
invasive, easy to administer, and easy to store. However, drug formulation for oral …

[HTML][HTML] Hot melt extruded posaconazole-based amorphous solid dispersions—The effect of different types of polymers

D Kramarczyk, J Knapik-Kowalczuk, M Kurek… - Pharmaceutics, 2023 - mdpi.com
Four model polymers, representing (i) amorphous homopolymers (Kollidon K30, K30),(ii)
amorphous heteropolymers (Kollidon VA64, KVA),(iii) semi-crystalline homopolymers …

Highly porous and drug-loaded amorphous solid dispersion microfiber scaffolds of indomethacin prepared by melt electrowriting

L Keßler, Z Mirzaei, JC Kade… - ACS Applied Polymer …, 2023 - ACS Publications
Melt electrowriting (MEW) is an additive manufacturing technology enabling the production
of highly porous microfiber scaffolds, suggested in particular for use in biomedical …

Hot-melt extrusion: a roadmap for product development

MF Simões, RMA Pinto, S Simões - AAPS PharmSciTech, 2021 - Springer
Hot-melt extrusion has found extensive application as a feasible pharmaceutical
technological option over recent years. HME applications include solubility enhancement …

Preparation and Characterization of a Rifampicin Coamorphous Material with Tromethamine Coformer: An Experimental–Theoretical Study

LHS Queiroz, RS Barros, FF de Sousa… - Molecular …, 2024 - ACS Publications
Rifampicin (RIF) is an antibiotic used to treat tuberculosis and leprosy. Even though RIF is a
market-available drug, it has a low aqueous solubility, hindering its bioavailability. Among …

Insight into the dissolution behavior of valsartan (form E) in twelve pure solvents: Solubility, modelling and molecular simulation

H Zhang, Y Zhang, F Xue, H Chen, Z Gao, S Du… - Journal of Molecular …, 2024 - Elsevier
Valsartan is an angiotensin II receptor antagonist used to treat hypertension. Crystals of
valsartan were prepared and the stability of the valsartan (form E) at different solvents and …

Emerging applications of hydroxypropyl methylcellulose acetate succinate: different aspects in drug delivery and its commercial potential

M Choudhari, S Damle, RN Saha, SK Dubey… - AAPS …, 2023 - Springer
Hydroxypropyl methylcellulose acetate succinate (HPMCAS) has multi-disciplinary
applications spanning across the development of drug delivery systems, in 3D printing, and …