A systematic and robust assessment of hot-melt extrusion-based amorphous solid dispersions: Theoretical prediction to practical implementation
A Alzahrani, D Nyavanandi, P Mandati… - International Journal of …, 2022 - Elsevier
Amorphous solid dispersions (ASDs) have gained attention as a formulation strategy in
recent years, with the potential to improve the apparent solubility and, hence, the oral …
recent years, with the potential to improve the apparent solubility and, hence, the oral …
Crystallinity: a complex critical quality attribute of amorphous solid dispersions
DE Moseson, LS Taylor - Molecular Pharmaceutics, 2023 - ACS Publications
Does the performance of an amorphous solid dispersion rely on having 100% amorphous
content? What specifications are appropriate for crystalline content within an amorphous …
content? What specifications are appropriate for crystalline content within an amorphous …
Transition Metal-Decorated B12N12–X (X = Au, Cu, Ni, Os, Pt, and Zn) Nanoclusters as Biosensors for Carboplatin
Theoretical studies on the adsorption, sensibility, and reactivity of a boron nitride nanocage
decorated with Au, Cu, Ni, Os, Pt, and Zn metals as a biosensor material were carried out for …
decorated with Au, Cu, Ni, Os, Pt, and Zn metals as a biosensor material were carried out for …
Strategies to improve the stability of amorphous solid dispersions in view of the hot melt extrusion (HME) method
ALJ Khater, SH Almurisi, S Mahmood… - International Journal of …, 2023 - Elsevier
Oral administration of drugs is preferred over other routes for several reasons: it is non-
invasive, easy to administer, and easy to store. However, drug formulation for oral …
invasive, easy to administer, and easy to store. However, drug formulation for oral …
[HTML][HTML] Hot melt extruded posaconazole-based amorphous solid dispersions—The effect of different types of polymers
Four model polymers, representing (i) amorphous homopolymers (Kollidon K30, K30),(ii)
amorphous heteropolymers (Kollidon VA64, KVA),(iii) semi-crystalline homopolymers …
amorphous heteropolymers (Kollidon VA64, KVA),(iii) semi-crystalline homopolymers …
Highly porous and drug-loaded amorphous solid dispersion microfiber scaffolds of indomethacin prepared by melt electrowriting
Melt electrowriting (MEW) is an additive manufacturing technology enabling the production
of highly porous microfiber scaffolds, suggested in particular for use in biomedical …
of highly porous microfiber scaffolds, suggested in particular for use in biomedical …
Hot-melt extrusion: a roadmap for product development
MF Simões, RMA Pinto, S Simões - AAPS PharmSciTech, 2021 - Springer
Hot-melt extrusion has found extensive application as a feasible pharmaceutical
technological option over recent years. HME applications include solubility enhancement …
technological option over recent years. HME applications include solubility enhancement …
Preparation and Characterization of a Rifampicin Coamorphous Material with Tromethamine Coformer: An Experimental–Theoretical Study
LHS Queiroz, RS Barros, FF de Sousa… - Molecular …, 2024 - ACS Publications
Rifampicin (RIF) is an antibiotic used to treat tuberculosis and leprosy. Even though RIF is a
market-available drug, it has a low aqueous solubility, hindering its bioavailability. Among …
market-available drug, it has a low aqueous solubility, hindering its bioavailability. Among …
Insight into the dissolution behavior of valsartan (form E) in twelve pure solvents: Solubility, modelling and molecular simulation
H Zhang, Y Zhang, F Xue, H Chen, Z Gao, S Du… - Journal of Molecular …, 2024 - Elsevier
Valsartan is an angiotensin II receptor antagonist used to treat hypertension. Crystals of
valsartan were prepared and the stability of the valsartan (form E) at different solvents and …
valsartan were prepared and the stability of the valsartan (form E) at different solvents and …
Emerging applications of hydroxypropyl methylcellulose acetate succinate: different aspects in drug delivery and its commercial potential
Hydroxypropyl methylcellulose acetate succinate (HPMCAS) has multi-disciplinary
applications spanning across the development of drug delivery systems, in 3D printing, and …
applications spanning across the development of drug delivery systems, in 3D printing, and …