The intersecting pandemics of tuberculosis and COVID-19: population-level and patient-level impact, clinical presentation, and corrective interventions
K Dheda, T Perumal, H Moultrie, R Perumal… - The Lancet …, 2022 - thelancet.com
The global tuberculosis burden remains substantial, with more than 10 million people newly
ill per year. Nevertheless, tuberculosis incidence has slowly declined over the past decade …
ill per year. Nevertheless, tuberculosis incidence has slowly declined over the past decade …
The COVID-19 and TB syndemic: the way forward
A Trajman, I Felker, LC Alves, I Coutinho… - … of Tuberculosis and …, 2022 - ingentaconnect.com
Together, SARS-CoV-2 and M. tuberculosis have killed approximately 5.7 million people
worldwide over the past 2 years. The COVID-19 pandemic, and the non-pharmaceutical …
worldwide over the past 2 years. The COVID-19 pandemic, and the non-pharmaceutical …
Bacterial-induced or passively administered interferon gamma conditions the lung for early control of SARS-CoV-2
KL Hilligan, S Namasivayam, CS Clancy… - Nature …, 2023 - nature.com
Abstract Type-1 and type-3 interferons (IFNs) are important for control of viral replication;
however, less is known about the role of Type-2 IFN (IFNγ) in anti-viral immunity. We …
however, less is known about the role of Type-2 IFN (IFNγ) in anti-viral immunity. We …
Clp-targeting BacPROTACs impair mycobacterial proteostasis and survival
DM Hoi, S Junker, L Junk, K Schwechel, K Fischel… - Cell, 2023 - cell.com
Summary The ClpC1: ClpP1P2 protease is a core component of the proteostasis system in
mycobacteria. To improve the efficacy of antitubercular agents targeting the Clp protease …
mycobacteria. To improve the efficacy of antitubercular agents targeting the Clp protease …
Co-infection of mice with SARS-CoV-2 and Mycobacterium tuberculosis limits early viral replication but does not affect mycobacterial loads
PJ Baker, EP Amaral, E Castro, AC Bohrer… - Frontiers in …, 2023 - frontiersin.org
Viral co-infections have been implicated in worsening tuberculosis (TB) and during the
COVID-19 pandemic, the global rate of TB-related deaths has increased for the first time in …
COVID-19 pandemic, the global rate of TB-related deaths has increased for the first time in …
[HTML][HTML] Real-time impact of COVID-19 on clinical care and treatment of patients with tuberculosis: a multicenter cross-sectional study in Addis Ababa, Ethiopia
D Chilot, Y Woldeamanuel… - Annals of Global Health, 2021 - ncbi.nlm.nih.gov
Background: There were global concerns and predictions that Coronavirus disease 2019
(COVID-19) would severely affect tuberculosis (TB) care and treatment services in resource …
(COVID-19) would severely affect tuberculosis (TB) care and treatment services in resource …
Pathogenesis of SARS-CoV-2 and Mycobacterium tuberculosis Coinfection
Coronavirus disease-2019 (COVID-19), caused by SARS-CoV-2, is an infectious disease
that poses severe threats to global public health and significant economic losses. The …
that poses severe threats to global public health and significant economic losses. The …
Immune responses in COVID-19 and tuberculosis coinfection: A scoping review
K Flores-Lovon, B Ortiz-Saavedra… - Frontiers in …, 2022 - frontiersin.org
Background and aim Patients with COVID-19 and tuberculosis coinfection are at an
increased risk of severe disease and death. We therefore sought to evaluate the current …
increased risk of severe disease and death. We therefore sought to evaluate the current …
Impact of COVID-19 on tuberculosis indicators in Brazil: a time series and spatial analysis study
TZ Berra, ACV Ramos, YM Alves, RBV Tavares… - Tropical Medicine and …, 2022 - mdpi.com
Background: We aimed to visualize and classify the time series of COVID-19, tuberculosis
(TB) notification, and TB outcomes (cure, treatment abandonment, and death), verify the …
(TB) notification, and TB outcomes (cure, treatment abandonment, and death), verify the …
The impact of the COVID-19 pandemic on the global tuberculosis epidemic
D Falzon, M Zignol, M Bastard, K Floyd… - Frontiers in …, 2023 - frontiersin.org
Tuberculosis (TB) is a major cause of ill health worldwide. Until the coronavirus (COVID-19)
pandemic, TB was the leading cause of death from a single infectious agent. COVID-19 has …
pandemic, TB was the leading cause of death from a single infectious agent. COVID-19 has …