Hypoxia triggers diverse cell physiological processes, and the hypoxia inducible factors
(HIFs) are a family of heterodimeric transcription factors that function as master regulators to …

Duplication of ancestral hypoxia-inducible factor (HIF) α coincided with the evolution of
vertebrate species. Paralogs HIF1α and HIF2α are the most well-known factors for …

Abstract The Ediacaran–Cambrian (E–C) transition witnessed profound biological and
oceanic changes, among which the appearance of explosive radiation of skeletonized …

Metazoans respond to hypoxic stress via the hypoxia-inducible factor (HIF) pathway, a
mechanism thought to be extremely conserved due to its importance in monitoring cellular …

Background The aquiferous system in sponges represents one of the simplest circulatory
systems used by animals for the internal uptake and distribution of oxygen and metabolic …

The title usage of Unde venisti 'from where have you come'is from a now dead language
(Latin) that foundationally influenced modern English (not the major influence, but an …

Hypoxia-inducible factors are heterodimeric transcription factors that play a crucial role in a
cell's ability to adapt to low oxygen. The von Hippel-Lindau tumor suppressor (pVHL) acts as …

The response to oxygen availability is a fundamental process concerning metabolism and
survival/death in all mitochondria-containing eukaryotes. However, the known oxygen …

Many aspects of the Late Ordovician Mass Extinction (LOME) aftermath and recovery have
been puzzling due to heterogeneities in tempo and triggering mechanisms. Benthic fossil …

What makes an animal? To find the answer we need to integrate data from disciplines such
as phylogenetics, paleontology, ecology, development, anatomy, and physiology, as well as …