Human cartilage biomechanics: experimental and theoretical approaches towards the identification of mechanical properties in healthy and osteoarthritic conditions
Articular cartilage is a complex connective tissue with the fundamental functions of load
bearing, shock absorption and lubrication in joints. However, traumatic events, aging and …
bearing, shock absorption and lubrication in joints. However, traumatic events, aging and …
Viscoelasticity in natural tissues and engineered scaffolds for tissue reconstruction
Viscoelasticity of living tissues plays a critical role in tissue homeostasis and regeneration,
and its implication in disease development and progression is being recognized recently. In …
and its implication in disease development and progression is being recognized recently. In …
Mussel-inspired tissue-adhesive hydrogel based on the polydopamine–chondroitin sulfate complex for growth-factor-free cartilage regeneration
Glycosaminoglycan-based hydrogels are widely used for cartilage repair because
glycosaminoglycans are the main component of the cartilage extracellular matrix and can …
glycosaminoglycans are the main component of the cartilage extracellular matrix and can …
Hypoxia-inducible factor-2α is a catabolic regulator of osteoarthritic cartilage destruction
S Yang, J Kim, JH Ryu, H Oh, CH Chun, BJ Kim… - Nature medicine, 2010 - nature.com
Osteoarthritic cartilage destruction is caused by an imbalance between anabolic and
catabolic factors. Here, we show that hypoxia-inducible factor-2α (HIF-2α, encoded by …
catabolic factors. Here, we show that hypoxia-inducible factor-2α (HIF-2α, encoded by …
Early detection of aging cartilage and osteoarthritis in mice and patient samples using atomic force microscopy
The pathological changes in osteoarthritis—a degenerative joint disease prevalent among
older people—start at the molecular scale and spread to the higher levels of the architecture …
older people—start at the molecular scale and spread to the higher levels of the architecture …
The effect of ageing and osteoarthritis on the mechanical properties of cartilage and bone in the human knee joint
Osteoarthritis is traditionally associated with cartilage degeneration although is now widely
accepted as a whole-joint disease affecting the entire osteochondral unit; however site …
accepted as a whole-joint disease affecting the entire osteochondral unit; however site …
Biohybrid methacrylated gelatin/polyacrylamide hydrogels for cartilage repair
Articular cartilage defect repair is challenging for clinics because of the lack of self-
regenerative ability of avascular tissue. Gelatin-based hydrogels are widely used in the field …
regenerative ability of avascular tissue. Gelatin-based hydrogels are widely used in the field …
[PDF][PDF] Cartilage integration: evaluation of the reasons for failure of integration during cartilage repair. A review
IM Khan, SJ Gilbert, SK Singhrao, VC Duance… - Eur Cell …, 2008 - ecmjournal.org
Articular cartilage is a challenging tissue to reconstruct or replace principally because of its
avascular nature; large chondral lesions in the tissue do not spontaneously heal. Where …
avascular nature; large chondral lesions in the tissue do not spontaneously heal. Where …
[HTML][HTML] Cellular modulation by the mechanical cues from biomaterials for tissue engineering
Q Wei, S Wang, F Han, H Wang, W Zhang… - Biomaterials …, 2021 - ncbi.nlm.nih.gov
Mechanical cues from the extracellular matrix (ECM) microenvironment are known to be
significant in modulating the fate of stem cells to guide developmental processes and …
significant in modulating the fate of stem cells to guide developmental processes and …
Silk fibroin hydrogel scaffolds incorporated with chitosan nanoparticles repair articular cartilage defects by regulating TGF-β1 and BMP-2
Y Li, Y Liu, Q Guo - Arthritis Research & Therapy, 2021 - Springer
Cartilage defects frequently occur around the knee joint yet cartilage has limited self-repair
abilities. Hydrogel scaffolds have excellent potential for use in tissue engineering. Therefore …
abilities. Hydrogel scaffolds have excellent potential for use in tissue engineering. Therefore …