The roles of NRF2 in modulating cellular iron homeostasis
MJ Kerins, A Ooi - Antioxidants & redox signaling, 2018 - liebertpub.com
Significance: Iron and oxygen are intimately linked: iron is an essential nutrient utilized as a
cofactor in enzymes for oxygen transport, oxidative phosphorylation, and metabolite …
cofactor in enzymes for oxygen transport, oxidative phosphorylation, and metabolite …
An insight into the health-promoting effects of taxifolin (dihydroquercetin)
C Sunil, B Xu - Phytochemistry, 2019 - Elsevier
Abstract Taxifolin (3, 5, 7, 3, 4-pentahydroxy flavanone or dihydroquercetin) is a flavonoid
commonly found in onion, milk thistle, French maritime pine bark and Douglas fir bark. It is …
commonly found in onion, milk thistle, French maritime pine bark and Douglas fir bark. It is …
An update of Nrf2 activators and inhibitors in cancer prevention/promotion
F Pouremamali, A Pouremamali, M Dadashpour… - Cell Communication and …, 2022 - Springer
Abstract NF-E2-related factor 2 (Nrf2) protein is a basic-region leucine zipper transcription
factor that defends against endogenous or exogenous stressors. By inducing several …
factor that defends against endogenous or exogenous stressors. By inducing several …
Molecular basis of the Keap1–Nrf2 system
T Suzuki, M Yamamoto - Free Radical Biology and Medicine, 2015 - Elsevier
Abstract Nrf2 (NF-E2-related factor 2) is a master regulator of cellular responses against
environmental stresses. Nrf2 induces the expression of detoxification and antioxidant …
environmental stresses. Nrf2 induces the expression of detoxification and antioxidant …
Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates …
LE Tebay, H Robertson, ST Durant, SR Vitale… - Free Radical Biology …, 2015 - Elsevier
Abstract Nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) regulates the basal and stress-
inducible expression of a battery of genes encoding key components of the glutathione …
inducible expression of a battery of genes encoding key components of the glutathione …
Stress-sensing mechanisms and the physiological roles of the Keap1–Nrf2 system during cellular stress
T Suzuki, M Yamamoto - Journal of Biological Chemistry, 2017 - ASBMB
Transcription factor Nrf2 (NF-E2-related factor 2) is a master regulator of cellular responses
against environmental stresses. Nrf2 induces the expression of detoxification and …
against environmental stresses. Nrf2 induces the expression of detoxification and …
Covalent modifiers: A chemical perspective on the reactivity of α, β-unsaturated carbonyls with thiols via hetero-Michael addition reactions
PA Jackson, JC Widen, DA Harki… - Journal of medicinal …, 2017 - ACS Publications
Although Michael acceptors display a potent and broad spectrum of bioactivity, they have
largely been ignored in drug discovery because of their presumed indiscriminate reactivity …
largely been ignored in drug discovery because of their presumed indiscriminate reactivity …
The Nrf2 regulatory network provides an interface between redox and intermediary metabolism
JD Hayes, AT Dinkova-Kostova - Trends in biochemical sciences, 2014 - cell.com
Nuclear factor-erythroid 2 p45-related factor 2 (Nrf2, also called Nfe2l2) is a transcription
factor that regulates the cellular redox status. Nrf2 is controlled through a complex …
factor that regulates the cellular redox status. Nrf2 is controlled through a complex …
Role of Nrf2 and its activators in respiratory diseases
Q Liu, Y Gao, X Ci - Oxidative medicine and cellular longevity, 2019 - Wiley Online Library
Transcription factor nuclear factor erythroid 2‐related factor 2 (Nrf2) is a major regulator of
antioxidant response element‐(ARE‐) driven cytoprotective protein expression. The …
antioxidant response element‐(ARE‐) driven cytoprotective protein expression. The …
[HTML][HTML] Beyond repression of Nrf2: An update on Keap1
Abstract Nrf2 (NFE2L2–nuclear factor (erythroid-derived 2)-like 2) is a transcription factor,
which is repressed by interaction with a redox-sensitive protein Keap1 (Kelch-like ECH …
which is repressed by interaction with a redox-sensitive protein Keap1 (Kelch-like ECH …