Inflammation clearly occurs in pathologically vulnerable regions of the Alzheimer's disease
(AD) brain, and it does so with the full complexity of local peripheral inflammatory responses …

Lymphatic vasculature drains interstitial fluids, which contain the tissue's waste products,
and ensures immune surveillance of the tissues, allowing immune cell recirculation. Until …

Background. Senile systemic amyloidosis (SSA) is characterized by deposition of wild‐type
transthyretin (TTR)‐based amyloid in parenchymal organs in elderly individuals. Previously …

In Chance, Development, and Aging, two leading biological gerontologists review and
evaluate all of the available data to elucidate the respective roles played by genes and …

A prominent feature of brain pathology in Alzheimer's disease is a robust activation of the
neuronal lysosomal system and major cellular pathways converging on the lysosome …

Alzheimer's disease (AD) is the most common type of dementia in the elderly population.
Three genes have been identified as responsible for the rare early-onset familial form of the …

Receptor for Advanced Glycation Endproducts (RAGE) is a member of the immunoglobulin
superfamily of cell surface molecules capable of interacting with a broad spectrum of …

Alpha‐macroglobulins are ancient proteins that include monomeric, dimeric, and tetrameric
family members. In humans, and many other mammals, the predominant alpha …

The processing of amyloid precursor protein (APP) generates amyloid-β (Aβ) peptides 1–40
and 1–42. The latter is neurotoxic and its accumulation results in amyloid fibril formation and …

The low-density lipoprotein (LDL) receptor-related protein (LRP) is a multifunctional
endocytic receptor that is expressed abundantly in neurons of the CNS. Both LRP and …