Human T-lymphotropic virus type 1 and novel coronavirus disease 2019; More complex than just a simple coinfection

S Sajjadi, S Hejazi, S Ravanshad, RJ Esfehani - Gene, 2022 - Elsevier
The recent coronavirus disease 2019 (COVID-19) significantly affected many people
worldwide, especially those with underlying diseases. While some people with underlying …

[HTML][HTML] LncRNAs related key pathways and genes in ischemic stroke by weighted gene co-expression network analysis (WGCNA)

M Wang, L Wang, L Pu, K Li, T Feng, P Zheng, S Li… - Genomics, 2020 - Elsevier
Background Ischemic stroke (IS) was a significant public health concern and long-chain
noncoding RNAs (lncRNAs) were gaining particular importance in stroke biology, however …

Pathogenicity and virulence of human T lymphotropic virus type-1 (HTLV-1) in oncogenesis: adult T-cell leukemia/lymphoma (ATLL)

S Ahmadi Ghezeldasht, DJ Blackbourn… - Critical Reviews in …, 2023 - Taylor & Francis
Adult T-cell leukemia/lymphoma (ATLL) is an aggressive malignancy of CD4+ T
lymphocytes caused by human T lymphotropic virus type-1 (HTLV-1) infection. HTLV-1 was …

Selective APC-targeting of a novel Fc-fusion multi-immunodominant recombinant protein (tTax-tEnv: mFcγ2a) for HTLV-1 vaccine development

M Shafifar, SH Mozhgani, KR Pashabayg, A Mosavat… - Life Sciences, 2022 - Elsevier
Aims HTLV-1 causes two life-threatening diseases: adult T-cell leukaemia/lymphoma and
HTLV-1-associated myelopathy/tropical spastic paraparesis. Due to the lack of proper …

[HTML][HTML] Coevolution of HTLV-1-HBZ, Tax, and proviral load with host IRF-1 and CCNA-2 in HAM/TSP patients

M Saffari, M Rahimzada, A Mirhosseini… - Infection, Genetics and …, 2022 - Elsevier
Abstract Background HTLV-1-associated myelopathy (HAM/TSP) is a progressive
neurodegenerative inflammatory condition of HTLV-1 infection. Viral-host interactions are a …

HTLV-1-host interactions facilitate the manifestations of cardiovascular disease

FS Mohammadi, A Mosavat, M Shabestari… - Microbial …, 2019 - Elsevier
Atherosclerosis is a multifactorial life-threatening disease which an epidemiologic study in
Northeastern Iran showed its association with HTLV-1 infection. Therefore, a cross-sectional …

Epigenetics evaluation of the oncogenic mechanisms of two closely related bovine and human deltaretroviruses: A system biology study

F Ashrafi, M Nassiri, A Javadmanesh, H Rahimi… - Microbial …, 2020 - Elsevier
Human T-cell lymphotropic virus (HTLV-1) and bovine leukemia virus (BLV) are oncogenic
deltaretroviruses, which are the cause of adult T cell leukemia/lymphoma (ATLL) and …

Influence of immunogenetic biomarkers in the clinical outcome of HTLV-1 infected persons

ACR Vallinoto, I Cayres-Vallinoto, MA Freitas Queiroz… - Viruses, 2019 - mdpi.com
Human T-lymphotropic virus 1, a member of the Retroviridae family, causes a neglected,
silent, persistent infection affecting circa 5 to 10 million people around the world, with …

Establishment of a cynomolgus macaque model of human T-cell leukemia virus type 1 (HTLV-1) infection by direct inoculation of adult T-cell leukemia patient-derived …

E Urano, K Ueda, M Higuchi, M Furukawa… - Journal of …, 2022 - Am Soc Microbiol
HTLV-1 was discovered in the 1980s as the causative agent of adult T-cell leukemia and
HTLV-1-associated myelopathy/tropical spastic paraparesis. However, the precise …

Production and Evaluation of Ag85B: HspX: hFcγ1 Immunogenicity as an Fc Fusion Recombinant Multi-Stage Vaccine Candidate Against Mycobacterium tuberculosis

M Karbalaei, A Mosavat, S Soleimanpour… - Current …, 2024 - Springer
An urgent need is to introduce an effective vaccine against Mycobacterium tuberculosis (M.
tb) infection. In the present study, a multi-stage M. tb immunodominant Fcγ1 fusion protein …