Hepatocellular carcinoma is the most prevalent form of primary liver cancer with a
multifactorial aetiology comprising genetic, environmental, and behavioural factors. Evading …

Members of the Bcl-2-protein family are key controllers of apoptotic cell death. The family is
divided into antiapoptotic (including Bcl-2 itself, Bcl-xL, Mcl-1, etc.) and proapoptotic …

The metabolic state represents a major hurdle for an effective adoptive T cell therapy (ACT).
Indeed, specific lipids can harm CD8+ T cell (CTL) mitochondrial integrity, leading to …

The low-density lipoprotein (LDL) is a major cholesterol carrier in circulation and is
internalized into cells through LDL receptor (LDLR)-mediated endocytosis. The LDLR …

Background The human CISD2 gene is located within a longevity region mapped on
chromosome 4q. In mice, Cisd2 levels decrease during natural aging and genetic studies …

Abstract The CISD2 (NAF-1) protein plays a key role in regulating cellular homeostasis,
aging, cancer and neurodegenerative diseases. It was found to control different calcium …

The liver plays a pivotal role in mammalian aging. However, the mechanisms underlying
liver aging remain unclear. Cisd2 is a pro‐longevity gene in mice. Cisd2 mediates lifespan …

Calcium ions (Ca2+) operate as important messengers in the cell, indispensable for
signaling the underlying numerous cellular processes in all of the cell types in the human …

Mutations in WFS1 (which encodes Wolframin, WFS1) and CISD2 (which encodes CDGSH
iron sulfur domain 2) result in Wolfram syndrome (WS), a rare genetic disorder that starts …

The aging human population with age-associated diseases has become a problem
worldwide. By 2050, the global population of those who are aged 65 years and older will …