Impact of multiple pathologies on the threshold for clinically overt dementia
Longitudinal clinical–pathological studies have increasingly recognized the importance of
mixed pathologies (the coexistence of one or more neurodegenerative and cerebrovascular …
mixed pathologies (the coexistence of one or more neurodegenerative and cerebrovascular …
Associations between amyloid β and white matter hyperintensities: a systematic review
Introduction This systematic review synthesizes current evidence for associations between
cortical amyloid β, visualized on amyloid positron emission tomography imaging, and white …
cortical amyloid β, visualized on amyloid positron emission tomography imaging, and white …
Interactive associations of vascular risk and β-amyloid burden with cognitive decline in clinically normal elderly individuals: findings from the Harvard Aging Brain …
JS Rabin, AP Schultz, T Hedden, A Viswanathan… - JAMA …, 2018 - jamanetwork.com
Importance Identifying asymptomatic individuals at high risk of impending cognitive decline
because of Alzheimer disease is crucial for successful prevention of dementia. Vascular risk …
because of Alzheimer disease is crucial for successful prevention of dementia. Vascular risk …
[HTML][HTML] Novel imaging techniques in cerebral small vessel diseases and vascular cognitive impairment
Dementia is a global growing concern, affecting over 35 million people with a global
economic impact of over $604 billion US. With an ageing population the number of people …
economic impact of over $604 billion US. With an ageing population the number of people …
Clinical effect of white matter network disruption related to amyloid and small vessel disease
Background: We tested our hypothesis that the white matter network might mediate the effect
of amyloid and small vessel disease (SVD) on cortical thickness and/or cognition. Methods …
of amyloid and small vessel disease (SVD) on cortical thickness and/or cognition. Methods …
Spreading of amyloid, tau, and microvascular pathology in Alzheimer's disease: findings from neuropathological and neuroimaging studies
Primary pathologies including amyloid-β (Aβ) plaques and neurofibrillary tangles (NFT)
develop many years before the onset of dementia symptoms in Alzheimer's disease (AD) …
develop many years before the onset of dementia symptoms in Alzheimer's disease (AD) …
Brain amyloid β, cerebral small vessel disease, and cognition: A memory clinic study
FN Saridin, S Hilal, SG Villaraza, A Reilhac… - Neurology, 2020 - AAN Enterprises
Objective To evaluate the association between brain amyloid β (Aβ) and cerebral small
vessel disease (CSVD) markers, as well as their joint effect on cognition, in a memory clinic …
vessel disease (CSVD) markers, as well as their joint effect on cognition, in a memory clinic …
[HTML][HTML] Interaction between Alzheimer's disease and cerebral small vessel disease: A review focused on neuroimaging markers
SE Kim, HJ Kim, H Jang, MW Weiner… - International journal of …, 2022 - mdpi.com
Alzheimer's disease (AD) is characterized by the presence of β-amyloid (Aβ) and tau, and
subcortical vascular cognitive impairment (SVCI) is characterized by cerebral small vessel …
subcortical vascular cognitive impairment (SVCI) is characterized by cerebral small vessel …
Amyloid positivity in the Alzheimer/subcortical-vascular spectrum
Objective We investigated the frequency of β-amyloid (Aβ) positivity in 9 groups classified
according to a combination of 3 different cognition states and 3 distinct levels of white matter …
according to a combination of 3 different cognition states and 3 distinct levels of white matter …
[HTML][HTML] Performance of the plasma Aβ42/Aβ40 ratio, measured with a novel HPLC-MS/MS method, as a biomarker of amyloid PET status in a DPUK-KOREAN cohort
Background We assessed the feasibility of plasma Aβ42/Aβ40 determined using a novel
liquid chromatography-mass spectrometry method (LC-MS) as a useful biomarker of PET …
liquid chromatography-mass spectrometry method (LC-MS) as a useful biomarker of PET …