[HTML][HTML] Genetics-based risk scores for prediction of premature coronary artery disease

R Gupta - Indian Heart Journal, 2023 - Elsevier
Premature coronary artery disease (CAD) is endemic in India. Global Burden of Diseases
study has reported that it led to 286,000 deaths in 2019 in India. Many of these patients have …

[HTML][HTML] The Inclusion of Underrepresented Populations in Cardiovascular Genetics and Epidemiology

E Chappell, L Arbour, Z Laksman - Journal of Cardiovascular …, 2024 - mdpi.com
Novel genetic risk markers have helped us to advance the field of cardiovascular
epidemiology and refine our current understanding and risk stratification paradigms. The …

[HTML][HTML] A proteomic analysis of atrial fibrillation in a prospective longitudinal cohort (AGES-Reykjavik study)

T Jonmundsson, AE Steindorsdottir, TR Austin… - Europace, 2023 - academic.oup.com
Aims Atrial fibrillation (AF) is associated with high risk of comorbidities and mortality. Our aim
was to examine causal and predictive relationships between 4137 serum proteins and …

Atherosclerotic cardiovascular disease risk prediction: current state-of-the-art

A Rout, S Duhan, M Umer, M Li, D Kalra - Heart, 2024 - heart.bmj.com
Cardiovascular disease (CVD) is the leading cause of mortality worldwide, resulting in~ 18
million deaths annually. 1 Atherosclerotic CVD (ASCVD) accounts for four out of every five …

[HTML][HTML] Validated WGS and WES protocols proved saliva-derived gDNA as an equivalent to blood-derived gDNA for clinical and population genomic analyses

K Kvapilova, P Misenko, J Radvanszky, O Brzon… - BMC genomics, 2024 - Springer
Background Whole exome sequencing (WES) and whole genome sequencing (WGS) have
become standard methods in human clinical diagnostics as well as in population genomics …

Assessing Tree-Based Phenotype Prediction on the UK Biobank

A Meléndez, C López, D Bonet, G Sant… - 2023 IEEE …, 2023 - ieeexplore.ieee.org
Precision medicine relies on the ability to identify associations between genomic data and
its phenotypic expression in order to provide personalized predictions. Phenotype prediction …

[HTML][HTML] Snoring-related polygenic risk and its relationship with lifestyle factors in a Korean population: KoGES study

B Ryu, S Lee, E Heo, S Yoo, JW Kim - Scientific Reports, 2023 - nature.com
Whereas lifestyle-related factors are recognized as snoring risk factors, the role of genetics
in snoring remains uncertain. One way to measure the impact of genetic risk is through the …

Identification of Novel Genes Associated with Atrial Fibrillation and Development of Atrial Fibrillation Predictive Models by Incorporating Polygenic Risk Scores and …

SY Chen, YC Chen, TY Liu, KC Chang, SS Chang… - medRxiv, 2023 - medrxiv.org
BACKGROUND: Atrial fibrillation (AF) is the most common atrial arrhythmia and is
subcategorized into numerous clinical phenotypes. Previous studies demonstrated that early …

The importance of different sources and sequencing protocols in increasing the accuracy of NGS analysis in diagnostic applications

K Kvapilová - 2024 - dspace.cuni.cz
Continued advances in next-generation sequencing (NGS) technology, such as capacity,
speed, and reduced cost per sequenced base, revolutionize personalized medicine and …

[HTML][HTML] Polygenic score to improve prediction of coronary artery disease in women under 45 years: The HUNT Study

K Skjærstein - 2024 - ntnuopen.ntnu.no
Introduction: Cardiovascular diseases are an immense health burden across the world. One
of the contributing diseases is coronary artery disease (CAD), with a mortality rate at 16 …