[HTML][HTML] Ylang-ylang (Cananga odorata (Lam.) Hook. f. & Thomson) essential oil reduced neuropathic-pain and associated anxiety symptoms in mice

V Borgonetti, V López, N Galeotti - Journal of ethnopharmacology, 2022 - Elsevier
Ethnopharmacological relevance Ylang-ylang essential oil (YEO), obtained from the flowers
of the tropical tree Cananga odorata (Lam.) Hook. f. & Thomson (family Annonaceae), has …

Rosmarinic acid reduces microglia senescence: a novel therapeutic approach for the management of neuropathic pain symptoms

V Borgonetti, N Galeotti - Biomedicines, 2022 - mdpi.com
The worldwide incidence of neuropathic pain is around 7–8% and is associated with
significant and disabling comorbidities (sleep disturbances, depression, anxiety). It is now …

Dual HDAC/BRD4 inhibitors relieves neuropathic pain by attenuating inflammatory response in microglia after spared nerve injury

V Borgonetti, E Meacci, F Pierucci, MN Romanelli… - …, 2022 - Springer
Despite the effort on developing new treatments, therapy for neuropathic pain is still a
clinical challenge and combination therapy regimes of two or more drugs are often needed …

Microglia senescence is related to neuropathic pain–associated comorbidities in the spared nerve injury model

V Borgonetti, N Galeotti - Pain, 2023 - journals.lww.com
The increased presence of senescent cells in different neurological diseases suggests the
contribution of senescence in the pathophysiology of neurodegenerative disorders …

Novel Combination of Choline with Withania somnifera (L.) Dunal, and Bacopa monnieri (L.) Wetts Reduced Oxidative Stress in Microglia Cells, Promoting …

V Borgonetti, N Galeotti - International journal of molecular sciences, 2023 - mdpi.com
Memory deficit is one of the major negative outcomes of chronic stress. Cholinergic system
modulates memory not only through the neuronal cells, but also via interactions with non …

A honokiol-enriched Magnolia officinalis Rehder & EH Wilson. bark extract possesses anxiolytic-like activity with neuroprotective effect through the modulation of CB1 …

V Borgonetti, P Governa, F Manetti… - Journal of Pharmacy …, 2021 - academic.oup.com
Objectives The exposure of neurons to an excessive excitatory stimulation induces the
alteration of the normal neuronal function. Mood disorders are among the first signs of …

Helichrysum stoechas (L.) Moench reduces body weight gain and modulates mood disorders via inhibition of silent information regulator 1 (SIRT1) by arzanol

V Borgonetti, C Caroli, P Governa… - Phytotherapy …, 2023 - Wiley Online Library
The prevalence of obesity is steadily rising, making safe and more efficient anti‐obesity
treatments an urgent medical need. Growing evidence correlates obesity and comorbidities …

Attenuation of Anxiety-Like Behavior by Helichrysum stoechas (L.) Moench Methanolic Extract through Up-Regulation of ERK Signaling Pathways in Noradrenergic …

V Borgonetti, F Les, V López, N Galeotti - Pharmaceuticals, 2020 - mdpi.com
The long-term use of anxiolytic and antidepressant drugs can cause a plethora of side
effects and the use of complementary and alternative medicine, which is generally …

[HTML][HTML] The Anxiolytic Effect of Polysaccharides from Stellariae Radix through Monoamine Neurotransmitters, HPA Axis, and ECS/ERK/CREB/BDNF Signaling …

M Ma, H Quan, S Chen, X Fu, L Zang, L Dong - Brain Research Bulletin, 2023 - Elsevier
Background Stellaria dichotoma L. var. lanceolata Bge. is renowned for its efficacy in"
clearing deficiency heat" and represents a significant traditional Chinese medicine (TCM) …

Investigation on the neuroprotective effect of a cannabidiol-enriched non-psychotropic Cannabis sativa L. extract in an in vitro model of excitotoxicity

V Borgonetti, M Biagi, N Galeotti, F Manetti, P Governa - Fitoterapia, 2022 - Elsevier
The purpose of this study was to evaluate the neuroprotective effect of a cannabidiol-
enriched non-psychotropic Cannabis sativa L. extract (CSE) and its main constituents …