Endothelial dysfunction plays a key role in the pathogenesis of diabetic vascular disease.
The endothelium controls the tone of the underlying vascular smooth muscle through the …

The control and maintenance of vascular tone is due to a balance between vasoconstrictor
and vasodilator pathways. Vasomotor responses to neural, metabolic and physical factors …

Although the chemical nature of endothelium-derived hyperpolarizing factor (EDHF) remains
elusive, electrophysiological evidence exists for electrical communication between smooth …

Both cGMP-dependent and-independent mechanisms have been implicated in the
regulation of vascular tone by NO. We analyzed acetylcholine (ACh)-and NO-induced …

Recent evidence suggests that functional diversity of vascular smooth muscle is produced in
part by a differential expression of ion channels. The aim of the present study was to …

Although diabetes is a major risk factor for vascular diseases, eg, hypertension and
atherosclerosis, mechanisms that underlie the “risky” aspects of diabetes remain obscure …

Le facteur hyperpolarisant provenant de l'endothélium, ou EDHF, est défini comme la
substance non-monoxyde d'azote (NO) et non-prostacycline (PGI2) qui véhicule …

Endothelial cells play a vital role in the maintenance of cardiovascular homeostasis.
Epoxyeicosatrienoic acids (EETs), cytochrome P-450 (CYP) epoxygenase metabolites of …

The possibility that stimulation of smooth muscle α1‐adrenoceptors modulates contraction
via the endothelium was examined in rat small mesenteric arteries. Nω‐nitro‐l‐arginine …

The vascular endothelium is strategically located between the circulating blood and the
vascular smooth muscle cells. Different agonists or stimuli transported by the circulating …