[HTML][HTML] Adipocytes from women with polycystic ovary syndrome demonstrate altered phosphorylation and activity of glycogen synthase kinase 3

W Chang, MO Goodarzi, H Williams, DA Magoffin… - Fertility and sterility, 2008 - Elsevier
OBJECTIVE: To test the hypothesis that an abnormality in glycogen synthase kinase-3
(GSK3) is a pathogenic factor in polycystic ovary syndrome (PCOS). DESIGN: Prospective …

Chronic selective glycogen synthase kinase-3 inhibition enhances glucose disposal and muscle insulin action in prediabetic obese Zucker rats

BB Dokken, EJ Henriksen - American Journal of Physiology …, 2006 - journals.physiology.org
Increasing evidence supports a negative role of glycogen synthase kinase-3 (GSK-3) in
regulation of skeletal muscle glucose transport. We assessed the effects of chronic treatment …

Maternal food restriction enhances insulin-induced GLUT-4 translocation and insulin signaling pathway in skeletal muscle from suckling rats

ML Gavete, MA Martin, C Alvarez, F Escrivá - Endocrinology, 2005 - academic.oup.com
Restriction of protein calories during stages of immaturity has a major influence on glucose
metabolism and increases the risk of type 2 diabetes in adulthood. However, it is known that …

Inhibition of GSK-3β restores delayed gastric emptying in obesity-induced diabetic female mice

C Sampath, S Srinivasan… - American Journal of …, 2020 - journals.physiology.org
Diabetic gastroparesis (DG) is a clinical syndrome characterized by delayed gastric
emptying (DGE). Loss of nuclear factor erythroid 2-related factor 2 (Nrf2) is associated with …

[HTML][HTML] Upregulation of GLUT4 and PI3K, and downregulation of GSK3 mediate the anti‑hyperglycemic effects of proanthocyanidins

NE El-Ashmawy, EG Khedr… - Medicine …, 2022 - spandidos-publications.com
Diabetes mellitus is the most common chronic metabolic disorder worldwide. The present
study was designed to investigate the potential role of cinnamon bark extract oligomeric …

[HTML][HTML] Long non-coding RNA LINC00222 regulates GSK3β activity and promotes cell apoptosis in lung adenocarcinoma

H Zhang, Y Wang, J Lu, Y Zhao - Biomedicine & Pharmacotherapy, 2018 - Elsevier
Recent evidence indicates that long noncoding RNAs (lncRNAs) play a critical role in the
regulating cellular processes such as differentiation, proliferation, metastasis and apoptosis …

[HTML][HTML] GSK3-Driven Modulation of Inflammation and Tissue Integrity in the Animal Model

F Kühl, K Brand, R Lichtinghagen, R Huber - International Journal of …, 2024 - mdpi.com
Nowadays, GSK3 is accepted as an enzyme strongly involved in the regulation of
inflammation by balancing the pro-and anti-inflammatory responses of cells and organisms …

Pharmacological inhibition of GSK-3β produces late phase of cardioprotection in hyperlipidemic rat: Possible involvement of HSP 72

HN Yadav, M Singh, PL Sharma - Molecular and cellular biochemistry, 2012 - Springer
The acute, as well as late, phase of cardioprotection induced by ischemic preconditioning is
abolished in hyperlipidemic (HL) rat heart. The pharmacological inhibition of glycogen …

Characterizing the effects of muscle-specific GSK3α/β reduction on murine muscle contractility and metabolism in female mice

BL Hockey, MS Finch, JL Braun… - … of Physiology-Cell …, 2024 - journals.physiology.org
Dysregulation of skeletal muscle morphology and metabolism is associated with chronic
diseases such as obesity and type 2 diabetes. The enzyme glycogen synthase kinase 3 …

Structure and regulation of glycogen synthase in the brain

BA Pederson - Brain Glycogen Metabolism, 2019 - Springer
Brain glycogen synthesis is a regulated, multi-step process that begins with glucose
transport across the blood brain barrier and culminates with the actions of glycogen …