Regulation of the PI-3 kinase (PI3K)/Akt signalling pathway is essential for maintaining the
integrity of fundamental cellular processes, cell growth, survival, death and metabolism, and …

Despite recent advances in our understanding of the biological behavior of prostate cancer
(PCa), PCa is becoming the most common malignancy in men worldwide. The …

Cancer immunoresistance and immune escape,, may play important roles in tumor
progression and pose obstacles for immunotherapy. Expression of the immunosuppressive …

Molecular genetic studies of familial cancer syndromes identified and defined the recessive
nature of tumor suppressor genes and resolved the paradox of why tumors arising in such …

Gain-of-function mutations in NOTCH1 are common in T-cell lymphoblastic leukemias and
lymphomas (T-ALL), making this receptor a promising target for drugs such as γ-secretase …

Phosphatidylinositol-3-kinase (PI3K) is an important target in cancer due to the deregulation
of the PI3K/Akt signaling pathway in a wide variety of tumors. A series of thieno [3, 2-d] …

The regulatory circuits that control the activities of the two distinct target of rapamycin (TOR)
complexes, TORC1 and TORC2, and of Akt have been a focus of intense research in recent …

Tyrosine phosphorylation is an important signalling mechanism in eukaryotic cells. In
cancer, oncogenic activation of tyrosine kinases is a common feature, and novel anticancer …

During random locomotion, human neutrophils and Dictyostelium discoideum amoebae
repeatedly extend and retract cytoplasmic processes. During directed cell migration …

The known classes of genes that function as tumor suppressors and oncogenes have
recently been expanded to include the microRNA (miRNA) family of regulatory molecules …