Advances and opportunities in malaria population genomics
Almost 20 years have passed since the first reference genome assemblies were published
for Plasmodium falciparum, the deadliest malaria parasite, and Anopheles gambiae, the …
for Plasmodium falciparum, the deadliest malaria parasite, and Anopheles gambiae, the …
Cryo-EM of helical polymers
F Wang, O Gnewou, A Solemanifar… - Chemical …, 2022 - ACS Publications
While the application of cryogenic electron microscopy (cryo-EM) to helical polymers in
biology has a long history, due to the huge number of helical macromolecular assemblies in …
biology has a long history, due to the huge number of helical macromolecular assemblies in …
Global genetic diversity, introgression, and evolutionary adaptation of indicine cattle revealed by whole genome sequencing
N Chen, X Xia, Q Hanif, F Zhang, R Dang… - Nature …, 2023 - nature.com
Indicine cattle, also referred to as zebu (Bos taurus indicus), play a central role in pastoral
communities across a wide range of agro-ecosystems, from extremely hot semiarid regions …
communities across a wide range of agro-ecosystems, from extremely hot semiarid regions …
Malaria protection due to sickle haemoglobin depends on parasite genotype
G Band, EM Leffler, M Jallow, F Sisay-Joof, CM Ndila… - Nature, 2022 - nature.com
Host genetic factors can confer resistance against malaria, raising the question of whether
this has led to evolutionary adaptation of parasite populations. Here we searched for …
this has led to evolutionary adaptation of parasite populations. Here we searched for …
[HTML][HTML] Plasmodium falciparum resistance to ACTs: Emergence, mechanisms, and outlook
Emergence and spread of resistance in Plasmodium falciparum to the frontline treatment
artemisinin-based combination therapies (ACTs) in the epicenter of multidrug resistance of …
artemisinin-based combination therapies (ACTs) in the epicenter of multidrug resistance of …
Host-malaria parasite interactions and impacts on mutual evolution
X Su, C Zhang, DA Joy - Frontiers in Cellular and Infection …, 2020 - frontiersin.org
Malaria is the most deadly parasitic disease, affecting hundreds of millions of people
worldwide. Malaria parasites have been associated with their hosts for millions of years …
worldwide. Malaria parasites have been associated with their hosts for millions of years …
Pathogenicity and virulence of malaria: Sticky problems and tricky solutions
IS Walker, SJ Rogerson - Virulence, 2023 - Taylor & Francis
Infections with Plasmodium falciparum and Plasmodium vivax cause over 600,000 deaths
each year, concentrated in Africa and in young children, but much of the world's population …
each year, concentrated in Africa and in young children, but much of the world's population …
Global diversity and balancing selection of 23 leading Plasmodium falciparum candidate vaccine antigens
Investigation of the diversity of malaria parasite antigens can help prioritize and validate
them as vaccine candidates and identify the most common variants for inclusion in vaccine …
them as vaccine candidates and identify the most common variants for inclusion in vaccine …
[PDF][PDF] Evolutionary genetics and admixture in African populations
A Pfennig, LN Petersen, P Kachambwa… - Genome Biology and …, 2023 - academic.oup.com
As the ancestral homeland of our species, Africa contains elevated levels of genetic diversity
and substantial population structure. Importantly, African genomes are heterogeneous: They …
and substantial population structure. Importantly, African genomes are heterogeneous: They …
The human genetic determinism of life-threatening infectious diseases: genetic heterogeneity and physiological homogeneity?
JL Casanova, L Abel - Human genetics, 2020 - Springer
Multicellular eukaryotes emerged late in evolution from an ocean of viruses, bacteria,
archaea, and unicellular eukaryotes. These macroorganisms are exposed to and infected by …
archaea, and unicellular eukaryotes. These macroorganisms are exposed to and infected by …