Advances and opportunities in malaria population genomics

DE Neafsey, AR Taylor, BL MacInnis - Nature Reviews Genetics, 2021 - nature.com
Almost 20 years have passed since the first reference genome assemblies were published
for Plasmodium falciparum, the deadliest malaria parasite, and Anopheles gambiae, the …

Cryo-EM of helical polymers

F Wang, O Gnewou, A Solemanifar… - Chemical …, 2022 - ACS Publications
While the application of cryogenic electron microscopy (cryo-EM) to helical polymers in
biology has a long history, due to the huge number of helical macromolecular assemblies in …

Global genetic diversity, introgression, and evolutionary adaptation of indicine cattle revealed by whole genome sequencing

N Chen, X Xia, Q Hanif, F Zhang, R Dang… - Nature …, 2023 - nature.com
Indicine cattle, also referred to as zebu (Bos taurus indicus), play a central role in pastoral
communities across a wide range of agro-ecosystems, from extremely hot semiarid regions …

Malaria protection due to sickle haemoglobin depends on parasite genotype

G Band, EM Leffler, M Jallow, F Sisay-Joof, CM Ndila… - Nature, 2022 - nature.com
Host genetic factors can confer resistance against malaria, raising the question of whether
this has led to evolutionary adaptation of parasite populations. Here we searched for …

[HTML][HTML] Plasmodium falciparum resistance to ACTs: Emergence, mechanisms, and outlook

FA Siddiqui, X Liang, L Cui - … Journal for Parasitology: Drugs and Drug …, 2021 - Elsevier
Emergence and spread of resistance in Plasmodium falciparum to the frontline treatment
artemisinin-based combination therapies (ACTs) in the epicenter of multidrug resistance of …

Host-malaria parasite interactions and impacts on mutual evolution

X Su, C Zhang, DA Joy - Frontiers in Cellular and Infection …, 2020 - frontiersin.org
Malaria is the most deadly parasitic disease, affecting hundreds of millions of people
worldwide. Malaria parasites have been associated with their hosts for millions of years …

Pathogenicity and virulence of malaria: Sticky problems and tricky solutions

IS Walker, SJ Rogerson - Virulence, 2023 - Taylor & Francis
Infections with Plasmodium falciparum and Plasmodium vivax cause over 600,000 deaths
each year, concentrated in Africa and in young children, but much of the world's population …

Global diversity and balancing selection of 23 leading Plasmodium falciparum candidate vaccine antigens

MT Naung, E Martin, J Munro, S Mehra… - PLoS Computational …, 2022 - journals.plos.org
Investigation of the diversity of malaria parasite antigens can help prioritize and validate
them as vaccine candidates and identify the most common variants for inclusion in vaccine …

[PDF][PDF] Evolutionary genetics and admixture in African populations

A Pfennig, LN Petersen, P Kachambwa… - Genome Biology and …, 2023 - academic.oup.com
As the ancestral homeland of our species, Africa contains elevated levels of genetic diversity
and substantial population structure. Importantly, African genomes are heterogeneous: They …

The human genetic determinism of life-threatening infectious diseases: genetic heterogeneity and physiological homogeneity?

JL Casanova, L Abel - Human genetics, 2020 - Springer
Multicellular eukaryotes emerged late in evolution from an ocean of viruses, bacteria,
archaea, and unicellular eukaryotes. These macroorganisms are exposed to and infected by …