Brain insulin resistance in Alzheimer's disease and related disorders: mechanisms and therapeutic approaches

D Kellar, S Craft - The Lancet Neurology, 2020 - thelancet.com
Insulin is a peptide secreted by the pancreas and plays an important role in the regulation of
glucose metabolism in peripheral tissues. Although the role of insulin in the periphery is well …

Altered glucose metabolism in Alzheimer's disease: Role of mitochondrial dysfunction and oxidative stress

S Dewanjee, P Chakraborty, H Bhattacharya… - Free Radical Biology …, 2022 - Elsevier
Increasing evidence suggests that abnormal cerebral glucose metabolism is largely present
in Alzheimer's disease (AD). The brain utilizes glucose as its main energy source and a …

[HTML][HTML] Type 3 diabetes and its role implications in Alzheimer's disease

TT Nguyen, QTH Ta, TKO Nguyen… - International journal of …, 2020 - mdpi.com
The exact connection between Alzheimer's disease (AD) and type 2 diabetes is still in
debate. However, poorly controlled blood sugar may increase the risk of developing …

[HTML][HTML] Glycogen synthase kinase-3 signaling in Alzheimer's disease

E Lauretti, O Dincer, D Praticò - … et Biophysica Acta (BBA)-Molecular Cell …, 2020 - Elsevier
Alzheimer's disease (AD) is the most common form of neurodegenerative disorder with
dementia, accounting for approximately 70% of the all cases. Currently, 5.8 million people in …

[HTML][HTML] The impact of disease comorbidities in Alzheimer's disease

JA Santiago, JA Potashkin - Frontiers in aging neuroscience, 2021 - frontiersin.org
A wide range of comorbid diseases is associated with Alzheimer's disease (AD), the most
common neurodegenerative disease worldwide. Evidence from clinical and molecular …

[HTML][HTML] The biological pathways of Alzheimer disease: A review

M Calabrò, C Rinaldi, G Santoro, C Crisafulli - AIMS neuroscience, 2021 - ncbi.nlm.nih.gov
Alzheimer disease is a progressive neurodegenerative disorder, mainly affecting older
people, which severely impairs patients' quality of life. In the recent years, the number of …

[HTML][HTML] Epigallocatechin-3-Gallate (EGCG): New therapeutic perspectives for neuroprotection, aging, and neuroinflammation for the modern age

A Payne, S Nahashon, E Taka, GM Adinew… - Biomolecules, 2022 - mdpi.com
Alzheimer's and Parkinson's diseases are the two most common forms of neurodegenerative
diseases. The exact etiology of these disorders is not well known; however, environmental …

Glucose metabolic crosstalk and regulation in brain function and diseases

S Zhang, BB Lachance, MP Mattson, X Jia - Progress in neurobiology, 2021 - Elsevier
Brain glucose metabolism, including glycolysis, the pentose phosphate pathway, and
glycogen turnover, produces ATP for energetic support and provides the precursors for the …

[HTML][HTML] Type 2 diabetes mellitus and Alzheimer's disease: shared molecular mechanisms and potential common therapeutic targets

R Hamzé, E Delangre, S Tolu, M Moreau… - International Journal of …, 2022 - mdpi.com
The global prevalence of diabetes mellitus and Alzheimer's disease is increasing alarmingly
with the aging of the population. Numerous epidemiological data suggest that there is a …

[HTML][HTML] New insights into the role and mechanisms of ginsenoside Rg1 in the management of Alzheimer's disease

J Wu, Y Yang, Y Wan, J Xia, JF Xu, L Zhang… - Biomedicine & …, 2022 - Elsevier
Alzheimer's disease (AD) is a common neurodegenerative disorder in the elderly
characterized by memory loss and cognitive dysfunction. The pathogenesis of AD is …