Functional vascular contributions to cognitive impairment and dementia: mechanisms and consequences of cerebral autoregulatory dysfunction, endothelial …
P Toth, S Tarantini, A Csiszar… - American Journal of …, 2017 - journals.physiology.org
Increasing evidence from epidemiological, clinical and experimental studies indicate that
age-related cerebromicrovascular dysfunction and microcirculatory damage play critical …
age-related cerebromicrovascular dysfunction and microcirculatory damage play critical …
Impaired neurovascular coupling in aging and Alzheimer's disease: contribution of astrocyte dysfunction and endothelial impairment to cognitive decline
The importance of (micro) vascular contributions to cognitive impairment and dementia
(VCID) in aging cannot be overemphasized, and the pathogenesis and prevention of age …
(VCID) in aging cannot be overemphasized, and the pathogenesis and prevention of age …
TRPV4: molecular conductor of a diverse orchestra
Transient receptor potential vanilloid type 4 (TRPV4) is a calcium-permeable nonselective
cation channel, originally described in 2000 by research teams led by Schultz (Nat Cell Biol …
cation channel, originally described in 2000 by research teams led by Schultz (Nat Cell Biol …
Membrane stretch as the mechanism of activation of PIEZO1 ion channels in chondrocytes
A Savadipour, RJ Nims, N Rashidi… - Proceedings of the …, 2023 - National Acad Sciences
Osteoarthritis is a chronic disease that can be initiated by altered joint loading or injury of the
cartilage. The mechanically sensitive PIEZO ion channels have been shown to transduce …
cartilage. The mechanically sensitive PIEZO ion channels have been shown to transduce …
[HTML][HTML] Direct measurement of TRPV4 and PIEZO1 activity reveals multiple mechanotransduction pathways in chondrocytes
The joints of mammals are lined with cartilage, comprised of individual chondrocytes
embedded in a specialized extracellular matrix. Chondrocytes experience a complex …
embedded in a specialized extracellular matrix. Chondrocytes experience a complex …
Transient receptor potential cation channels in disease
The transient receptor potential (TRP) superfamily consists of a large number of cation
channels that are mostly permeable to both monovalent and divalent cations. The 28 …
channels that are mostly permeable to both monovalent and divalent cations. The 28 …
The role of transient receptor potential cation channels in Ca2+ signaling
M Gees, B Colsoul, B Nilius - Cold Spring Harbor …, 2010 - cshperspectives.cshlp.org
The 28 mammalian members of the super-family of transient receptor potential (TRP)
channels are cation channels, mostly permeable to both monovalent and divalent cations …
channels are cation channels, mostly permeable to both monovalent and divalent cations …
TRP channels: an overview
SF Pedersen, G Owsianik, B Nilius - Cell calcium, 2005 - Elsevier
The TRP (“transient receptor potential”) family of ion channels now comprises more than 30
cation channels, most of which are permeable for Ca2+, and some also for Mg2+. On the …
cation channels, most of which are permeable for Ca2+, and some also for Mg2+. On the …
Abnormal osmotic regulation in trpv4-/- mice
W Liedtke, JM Friedman - Proceedings of the National …, 2003 - National Acad Sciences
Osmotic homeostasis is one of the most aggressively defended physiological parameters in
vertebrates. However, the molecular mechanisms underlying osmotic regulation are poorly …
vertebrates. However, the molecular mechanisms underlying osmotic regulation are poorly …
Pharmacology of vanilloid transient receptor potential cation channels
Depending on their primary structure, the 28 mammalian transient receptor potential (TRP)
cation channels identified so far can be sorted into 6 subfamilies: TRPC (“Canonical”), TRPV …
cation channels identified so far can be sorted into 6 subfamilies: TRPC (“Canonical”), TRPV …