Polygenic adaptation: a unifying framework to understand positive selection
Most adaption processes have a polygenic genetic basis, but even with the recent explosive
growth of genomic data we are still lacking a unified framework describing the dynamics of …
growth of genomic data we are still lacking a unified framework describing the dynamics of …
Harnessing genomic information for livestock improvement
M Georges, C Charlier, B Hayes - Nature Reviews Genetics, 2019 - nature.com
The world demand for animal-based food products is anticipated to increase by 70% by
2050. Meeting this demand in a way that has a minimal impact on the environment will …
2050. Meeting this demand in a way that has a minimal impact on the environment will …
[HTML][HTML] Polygenic prediction via Bayesian regression and continuous shrinkage priors
Polygenic risk scores (PRS) have shown promise in predicting human complex traits and
diseases. Here, we present PRS-CS, a polygenic prediction method that infers posterior …
diseases. Here, we present PRS-CS, a polygenic prediction method that infers posterior …
[HTML][HTML] Improved polygenic prediction by Bayesian multiple regression on summary statistics
Accurate prediction of an individual's phenotype from their DNA sequence is one of the great
promises of genomics and precision medicine. We extend a powerful individual-level data …
promises of genomics and precision medicine. We extend a powerful individual-level data …
False discovery rates: a new deal
M Stephens - Biostatistics, 2017 - academic.oup.com
We introduce a new Empirical Bayes approach for large-scale hypothesis testing, including
estimating false discovery rates (FDRs), and effect sizes. This approach has two key …
estimating false discovery rates (FDRs), and effect sizes. This approach has two key …
[HTML][HTML] Modeling linkage disequilibrium increases accuracy of polygenic risk scores
Polygenic risk scores have shown great promise in predicting complex disease risk and will
become more accurate as training sample sizes increase. The standard approach for …
become more accurate as training sample sizes increase. The standard approach for …
Genomic selection: a paradigm shift in animal breeding
T Meuwissen, B Hayes, M Goddard - Animal frontiers, 2016 - academic.oup.com
Traditional marker-assisted selection (MAS) did not result in a widespread use of DNA
information in animal breeding. The main reason was that the traits of interest in livestock …
information in animal breeding. The main reason was that the traits of interest in livestock …
Meta-analysis of genome-wide association studies for cattle stature identifies common genes that regulate body size in mammals
Stature is affected by many polymorphisms of small effect in humans. In contrast, variation in
dogs, even within breeds, has been suggested to be largely due to variants in a small …
dogs, even within breeds, has been suggested to be largely due to variants in a small …
Polygenic scores via penalized regression on summary statistics
Polygenic scores (PGS) summarize the genetic contribution of a person's genotype to a
disease or phenotype. They can be used to group participants into different risk categories …
disease or phenotype. They can be used to group participants into different risk categories …
Advantages and pitfalls in the application of mixed-model association methods
Mixed linear models are emerging as a method of choice for conducting genetic association
studies in humans and other organisms. The advantages of the mixed-linear-model …
studies in humans and other organisms. The advantages of the mixed-linear-model …