Microglia are usually referred to as “the innate immune cells of the brain,”“the resident
macrophages of the central nervous system”(CNS), or “CNS parenchymal macrophages.” …

Primary microglial leukodystrophy or leukoencephalopathy are disorders in which a genetic
defect linked to microglia causes cerebral white matter damage. Pigmented orthochromatic …

Microglia are brain-resident macrophages that contribute to central nervous system (CNS)
development, maturation, and preservation. Here, we examine the consequences of …

Mutations leading to colony‐stimulating factor‐1 receptor (CSF‐1R) loss‐of‐function or
haploinsufficiency cause CSF1R‐related leukoencephalopathy (CRL), an adult‐onset …

Mutations in the CSF1R gene are the most common cause of adult-onset
leukoencephalopathy with axonal spheroids and pigmented glia (ALSP), a …

Background There is an unmet need for the treatment of colony‐stimulating factor‐1 receptor
(CSF1R)‐related leukoencephalopathy. Objectives To evaluate the association of …

Background Colony‐stimulating factor 1 receptor (CSF1R)‐related disorder (CRD) is a rare
autosomal dominant disease. The clinical and genetic characteristics of Chinese patients …

Recent developments in adult-onset leukoencephalopathy with axonal spheroids and
pigmented glia (ALSP) and other disorders due to CSF1R variants led to the emergence of …

CSF1R mutations cause autosomal-dominant CSF1R-related leukoencephalopathy with
axonal spheroids and pigmented glia (CSF1R-ALSP) and autosomal-recessive brain …

Background Induced pluripotent stem cell-derived microglia (iMGL) represent an excellent
tool in studying microglial function in health and disease. Yet, since differentiation and …